Research

Lung Clearance Study

Standardization of Mucociliary Clearance Methodology in Cystic Fibrosis Patients

Protocol Description

The purpose of this study is to standardize the tests used to measure how fast mucus clears from the lungs. This test could eventually be used to determine whether new medications or therapies will help people with cystic fibrosis. There is evidence that people with cystic fibrosis have differences in the liquid that lines the surface of their lungs, causing their mucus to become dehydrated, thick and sticky, and limiting how well the hairs that line the breathing tubes (cilia) move mucus out of the lungs.

Eligibility Criteria

The study is currently accepting males and females ages 18 years and older, either diagnosed with cystic fibrosis or without cystic fibrosis as participants.
Males: 18 years and older
Females: 18 years and older

Requirements
In addition to the initial screening, participants will be administered various pulmonary function tests, some of which will include the use of special inhalants enabling photography of the lungs using a special “gamma camera.” Testing takes place at the Nuclear Medicine Department of UPMC Presbyterian .
Visits: 5
Duration: 2 weeks

Status: Open for Enrollment

Source of Support
Cystic Fibrosis Foundation