Research

Self-dispersing Liquids as Aerosol Drug Carriers

Aerosol Deposition in the Lungs of People with Cystic Fibrosis

Protocol Description

This study is being done to determine whether inhaled medications dissolved in surfactant-based (soap-like) solutions will distribute more evenly throughout the lungs when compared to standard saline-based (salt water) solutions. The ultimate goal is to improve the effectiveness of inhaled antibiotic medications used to treat cystic fibrosis. This study will use a special test called an aerosol deposition scan to compare how a drug spreads in the lungs, and will include subjects both with and without cystic fibrosis.

Eligibility Criteria

Males and females ages 18 and up, who have cystic fibrosis may be eligible to participate.
Males: Age 18 and up
Females: Age 18 and up

Requirements
Following a screening procedure, participants selected for the study will have two testing visits that will take place at the Nuclear Medicine Department of UPMC Presbyterian. In both visits, pulmonary function tests will be conducted and the participant will inhale radioactive test medications, after which a 3-dimensional lung scan will be performed.
Visits: 3
Duration: 1 month

Status: Open for Enrollment

Source of Support
Cystic Fibrosis Foundation Therapeutics

Additional Resources
Study Description at National Institutes of Health