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412-692-5630 Phone

412-692-6645 Fax

Job Title Assistant Professor of Pediatrics, University of Pittsburgh School of Medicine

4401 Penn Avenue, Suite Floor 3

Pittsburgh, PA 15224

412-692-5630 Phone

412-692-6645 Fax

Email shean.aujla@chp.edu

Medical School:	2000 Medical University of South Carolina, College of Medicine, Charleston, SC
Residency:	2004 Connecticut Children's Medical Center, University of Connecticut, Hartford, CT
Fellowship:	2007 Children's Hospital of Pittsburgh, Pittsburgh, PA

2001-2002 Outstanding PGY-2 Pediatric Resident of the Year, Connecticut Children's Medical Center
2005-2007 T32 Training Grant, Children's Hospital of Pittsburgh
Children's Hospital of Pittsburgh Scientific Award

The Role of IL-22 in Lung Host Defense, Cystic Fibrosis Center Seminar, 2006
Congenital Cystic Adenomatoid Malformations: Is Surgery Necessary for the Asymptomatic Patient? Joint Pediatric Pulmonology and Surgery Conference 2007
S.J. Aujla, A. Magill, A. Logar, P. Dubin, J.L. Kreindler and J.K. Kolls. Regulation of G-CSF and Clonogenic Potential in Human Bronchial Epithelium by IL-22 and IL-17. ATS 2007 Poster Discussion Session.

IL-22 is an IL-10 family cytokine member known to play a role in host defense in multiple organ systems including the intestine, skin and lung. It was recently shown to be produced primarily by Th17 cells of the immune system, which also produce the proinflammatory cytokine IL-17. IL-22 is made by these primary immune cells, and acts on its target tissues by way of its receptor, IL-22R. The IL-22R is not present on immune cells, but is expressed in skin, digestive tract, kidney and lung. Multiple studies have shown that IL-22 upregulates proinflammatory gene expression such as antimicrobial peptides, in skin and colon. We are currently studying the role of IL-22 in lung host defense in conjunction with IL-17 in a variety of in vivo and ex vivo models.