Research

Bone Forming Potential of Cells

Osteogenic Profiling of Tissue from Children with Craniosynostosis

Protocol Description

This study is being done to evaluate the osteogenic or bone-forming potential of certain cell types. It is hoped that, in the future, tissue can be engineered to slow down the fusion or closure of the bone and reduce the amount of surgery needed as the skull and the brain grows in craniosynostosis, a skull deformity caused by the premature fusion of skull bones during infancy causing problems with brain and skull growth.

Eligibility Criteria

Children of both genders, ages 2 months to 18 years and who are scheduled to undergo surgery for craniosynostosis, will be eligible for inclusion in this program.
Boys: 2 months to 18 years
Girls: 2 months to 18 years

Requirements
During reconstructive surgery for craniosynostosis, surgeons will collect a very small tissue sample from the side of the participant’s head, such as bone tissue that would normally be discarded during, as well as muscle and fat – combined about the size of a pencil eraser.
Visits: None beyond standard care for craniosynostosis.
Duration: Not applicable

Status: Open for Enrollment

Additional Resources
Study description at National Institutes of Health