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Margaretha Casselbrant, MD, PhD
Job Title Professor of Otolaryngology, University of Pittsburgh School of Medicine
4401 Penn Avenue, Suite Floor 3Pittsburgh, PA 15224
Education and Training
1973 University of Lund, Sweden
1978 University of Lund, Malmo General Hospital, Malmo, Sweden
1982 University of Pittsburgh School of Medicine, Pittsburgh, PA
- American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNS)
- American Laryngological, Rhinological and Otological Society (The Triological Society)
- American Society of Pediatric Otolaryngology (ASPO)
- Association for Research in Otolaryngology (ARO)
- European Society for Pediatric Otorhinolaryngology (ESPO)
- American Board of Otolaryngology
- 2003-2004, 2005-2006, 2007-2008, 2009-2010 Best Doctor
- Class of 2004-2005 Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program for Women
- 2008, 2009, 2010 Pittsburgh Magazine Top Doctors
- 2009-2010 Vice President, The Triological Society Eastern Section
- July 1, 2006-May 31, 2010 National Deafness and Other Communication Disorders Advisory Council of the National Institutes of Health
- Casselbrant ML, Mandel EM, Sparto PJ, Perera S, Redfern MS, Fall PA, Furman JM. Longitudinal posturography and rotational testing in children three to nine years of age: normative data. Otolaryngol Head Neck Surg 2010; 142(5):708-714.
- Casselbrant ML, Mandel EM, Rockette HE, Kurs-Lasky M, Fall PA, Bluestone CD. Adenoidectomy for otitis media with effusion in 2-3-year-old children. Int J Pediatr Otorhinolaryngol 2009; 73(12):1718-24.
- Casselbrant ML, Mandel EM, Jung J, Ferrell RE, Tekely K, Szatkiewicz JP, Ray A, Weeks DE. Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions. BMC Med Gen 2009; 10:85.
- Casselbrant ML, Mandel EM, Fall P, Rockette HE, Kurs-Lasky M, Bluestone CD, Ferrell RE. The Heritability of otitis media: A twin/triplet study. JAMA 1999; 8;282:2125-2130.
- Casselbrant ML, Redfern M, Furman JM, Fall P, Mandel EM. Visual induced postural sway in children with and without otitis media. Ann Otol Rhinol Laryngol 1998;107:401-405.
View Dr. Casselbrant's full list of publications from PubMed.
Through her research in the area of otitis media, also called middle ear disease, Children's Hospital of Pittsburgh of UPMC's Margaretha L. Casselbrant, MD, PhD, is fighting one of the most common infections for which children seek care.
Dr. Casselbrant's main areas of research are the prevention and treatment of otitis media, how it can affect balance and the hereditary aspects of the disease. Studies that Dr. Casselbrant and her colleagues have performed show that children who have fluid in their middle ear seem to be clumsier than children who do not and that balance improves after tympanostomy tubes have been inserted or the fluid goes away.
In the area of heredity, Dr. Casselbrant and her colleagues published a study in the Journal of the American Medical Association in 1999 that was conducted at Children's Hospital. They followed twins and triplets from birth to 5 years of age. They found a high genetic susceptibility to ear disease existed among these children. This study justified the next step - the search for the genes that put children at risk for developing the illness. By finding the genes, it would be possible to develop methodologies by which to determine which children are prone to the disease and also to develop new ways of treating otitis media. Dr. Casselbrant is applying for grants to find the genes and is beginning the search for siblings, at least two or more who have had ear tubes, to include in the study.
Dr. Casselbrant also is aware of the socioeconomic toll that the disease can take on the family of a sick child — missing work to go to the doctor and waking up in the middle of the night to care for an ailing child. She hopes her work to heal these children also can lessen the burden on parents.
Dr. Casselbrant is chief of the Division of Pediatric Otolaryngology at Children's Hospital of Pittsburgh of UPMC. She also is the Eberly Professor of Pediatric Otolaryngology and professor of Otolaryngology at the University of Pittsburgh School of Medicine.
Active Research Projects / Grants
- Medical and Surgical Management of Otitis Media
- Genetics of Otitis Media
- Otitis Media and Balance
- Balance Disorders in Children
- Middle Ear Pressure Regulation in Health and Disease
- Form/Function Predictors of Otitis Media
- Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion Social and Psychological Risk for Infectious Illness
July 2, 2014
July 2, 2014