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412-692-5630 Phone

412-692-7636 Fax

Juan C. Celedón, MD, DrPH

Job Title Chief of Service, Division of Pediatric Pulmonology, Allergy and Immunology, Children's Hospital of Pittsburgh of UPMC

Job Title Director, Center for Environmental Health, Children’s Hospital of Pittsburgh of UPMC

Job Title Neil K. Jerne Professor, Department of Pediatrics, University of Pittsburgh School of Medicine

Job Title Professor, Department of Medicine, University of Pittsburgh School of Medicine

Job Title Professor, Department of Human Genetics, Graduate School of Public Health at the University of Pittsburgh

Division of Pediatric Pulmonology

One Children's Hospital Drive
4401 Penn Ave., Suite Rangos Research Building, 9th Floor

Pittsburgh, PA 15224

412-692-5630 Phone

412-692-7636 Fax

Email juan.celedon@chp.edu

Profile
Active Research Projects

Education and Training

Medical School:	2001 DrPH, Epidemiology/Genetic Epidemiology, Harvard School of Public Health, Boston, MA 1999 MPH, Quantitative Methods, Harvard School of Public Health, Boston, MA 1988 MD, Pontificia Universidad Javeriana School of Medicine, Santa Fe de Bogotá, Colombia
Residency:	1992 Internal Medicine, Beth Israel Medical Center, The Mount Sinai School of Medicine, New York, NY
Fellowship:	2000 Research Fellow, Channing Laboratory, Brigham and Women’s Hospital, Boston, MA 1999 Research/Clinical Fellow, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 1995 Pulmonary/Critical Care Medicine, Brown University School of Medicine, Providence, RI

Memberships

American College of Physicians, Fellow
American College of Chest Physicians, Fellow
American Thoracic Society (ATS)
ATS Program and Budget Committee
ATS Scientific Review Committee
ATS Planning Committee, Environmental and Occupational Health (EOH) Assembly
ATS Program Committee, Environmental and Occupational Health (EOH) Assembly
ATS Epidemiology Working Group, EOH Assembly
American Society of Human Genetics
Federation of American Societies for Experimental Biology
American Academy of Allergy, Asthma, and Immunology, , Fellow (directly elected)

Board Certifications

American Board of Internal Medicine (ABIM), Diplomate
ABIM – Pulmonary Disease, Diplomate
ABIM – Critical Care Medicine, Diplomate

Awards

1985-1987 Student Representative to the Academic Council, Pontificia Universidad Javeriana School of Medicine
Best Graduate, Pontificia Universidad Javeriana School of Medicine
Charles A. King Trust Research Fellowship, The Medical Foundation, Boston, MA
Leadership Development for Physicians and Scientists, Harvard Medical School
Young Mentor Award, Harvard Medical School
Annual Faculty Teaching Award, Awarded for Outstanding Skill and Expertise as a Teacher of Human Genetics, Scholars in Clinical Science Program, Harvard Medical School
Brigham and Women’s Leadership Program, Brigham and Women’s Hospital and Harvard Business School
Member, American Society for Clinical Investigation
A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School
Leadership in Hispanic Health, National Hispanic Medical Association

Publications

Himes BE, Lasky-Su J, Wu AC, Wilk JB, Hunninghake GM, Klanderman B, Murphy AJ, Lazarus R, Soto-Quiros ME, Avila L, Celedón JC, Lange C, O'Connor GT, Raby BA, Silverman EK, Weiss ST. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Medical Genetics 2010; In Press.
Cohen R, Raby B, van Steen K, Fuhlbrigge A, Celedón JC, Rosner B, Strunk R, Zeiger R, Weiss ST. In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma. J Allergy Clin Immunol 2010; In Press.
Hunninghake GM, Soto-Quiros ME, Avila L, Kim HP, Lasky-Su J, Rafaels N, Ruczinski I, Beaty TH, Mathias R, Barnes KC, Wilk J, O’Connor G, Gauderman WJ, Vora H, Baurley JW, Gilliland F, Liang C, Sylvia J, Klanderman B, Sharma S, Himes B, Bossley C, Israel E, Raby B, Bush A, Choi A, Weiss S, Celedón JC.TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy 2010 Jun 17; Epub ahead of print.
Forno E, Fuhlbrigge A, Soto-Quiros ME, Avila L, Raby B, Brehm J, Sylvia J, Weiss ST, Celedón JC. Risk factors and predictive clinical score for asthma exacerbations in childhood. Chest 2010 May 14; Epub ahead of print.

View Dr. Celedón's full list of publications from PubMed.

Research Interests

I am a pulmonologist and genetic epidemiologist committed to research, teaching, mentoring, and clinical activities. My research goals are to identify genetic factors and early-life environmental exposures that influence the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) in general and among Hispanics in particular.

Few studies of the genetics or epidemiology of obstructive airway diseases have included Hispanics. To attempt to improve our understanding of the pathogenesis of asthma and COPD in Hispanics, I lead two studies of the genetics and epidemiology of obstructive airway diseases in individuals of Hispanic descent. The first study employs a family-based design to examine the relation between genetic variants and COPD in an isolated Hispanic population in the Central Valley of Costa Rica. The second study uses a case-control design to examine the relation among genetic variants, allergen exposure, and asthma in Puerto Ricans living in Hartford (CT) and in the island of Puerto Rico. To date, phenotypic and genotypic data have been collected in ~750 members of families of individuals with COPD in Costa Rica, and ~1,050 Puerto Rican children with and without asthma.

Because of my interest in the relation between microbial exposures and immune system development, I conducted a pilot study of the relation between the maternal and neonatal intestinal flora in early life and the development of asthma and allergies in childhood. Results from this pilot study will serve as preliminary data for a proposal for a Program Project Grant (PPG) on the relation between the intestinal flora in early life and allergic diseases.

I am keenly interested in mentoring the next generation of physician-scientists. I was deeply humbled and honored to be the first faculty member of Harvard Medical School to ever receive both the Young Mentor Award (2005) and the A. Clifford Barger Excellence in Mentoring Award (2010).

My clinical activities in pediatric and adult pulmonology sharpen my understanding of the phenotypes that are relevant to our studies on the genetic epidemiology of complex respiratory diseases.