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412-692-7366 Phone
412-692-5169 Fax

Constantinos Chrysostomou, MD

Job Title Assistant Professor, Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine
Job Title Staff, Cardiac Intensive Care Division
4401 Penn Avenue, Suite Floor 3
Pittsburgh, PA 15224
412-692-7366 Phone
412-692-5169 Fax

Education and Training

Medical School:

1996 University Medical School of Debrecen, Hungary


2001 Pediatrics, University of Minnesota


2003 Pedicatric Cardiology, Jackson Memorial Hospital/University of Miami, Miami, FL
2004 Pediatric Cardiology, Children's Hospital of Pittsburgh of UPMC/University of Pittsburgh, Pittsburgh, PA
2005  Pediatric Cardiac Critical Care, Children's Hospital of Pittsburgh of UPMC/University of Pittsburgh, Pittsburgh, PA


  • Pediatric Cardiac Intensive Care Society
  • Society of Critical Care Medicine
  • World Society of Pediatric and Congenital Heart Surgery, Founding Member

Board Certifications

  • American Board of Pediatrics, Fellow   
  • American Board of Pediatrics, Pediatric Cardiology


  • Chrysostomou C, De Toledo JS, Wearden P, Jooste EH, Lichtenstein SE, Callahan PM, Suresh T, O'Malley E, Shiderly D, Haney J, Yoshida M, Orr R, Munoz R, Morell VO. “Perioperative Use of Dexmedetomidine is Associated with Decreased Incidence of Ventricular and Supraventricular Tachyarrhythmias after Congenital Cardiac Surgery”. In Press Annals of Thoracic Surgery
  • De Toledo JS, Munoz R, Landsittel D, Shiderly D, Yoshida M, Komarlu R, Wearden P, Morell VO, Chrysostomou C: “Diagnosis of Abnormal Diaphragmatic Motion after Cardiothoracic Surgery: Ultrasound Performed by a Cardiac Intensivist vs. Fluoroscopy”. Congenit Heart Dis. 2010 Nov;5(6):565-72
  • Lazol J, Lichtenstein S, Jooste E, Shiderly D, Kudchadker N, Orr R, Wearden P, Morell VO, Munoz R, Chrysostomou C: “Effect of Dexmedetomidine on Pulmonary Artery Pressure after Congenital Cardiac Surgery”. Pediatr Crit Care Med. 2010 Sep;11(5):589-92.
  • Chrysostomou C,  Komarlu R, Lichtenstein S, Shiderly D, Arora G, Orr R, Wearden P, Morell VO, Munoz R, Jooste EH. “Electrocardiographic Effects of Dexmedetomidine in Patients with Congenital Heart Disease” Intensive Care Medicine, 2010 May;36(5):836-42
  • Chrysostomou C., Sanchez de Toledo J., Avolio T., Motoa V., Orr R., Berry D., Morell V., Munoz R.: “Dexmedetomidine Use in a Pediatric Cardiac Intensive Care Unit: Can We Use it in Infants after Cardiac Surgery?” Pediatr Crit Care Med. 2009 Nov;10(6):654-60
  • Chrysostomou C., Beerman L., Shiderly D., Berry D, Morell O. V., Munoz R. “Dexmedetomidine: A Novel Agent for the Treatment of Atrial and Junctional Tachyarrhythmias in Infants and Children after Cardiac Surgery”. Anesth Analg. 2008; 107(5):1514-22
  • Chrysostomou C., Schmitt. C. “Dexmedetomidine: Sedation, Analgesia and Beyond”. Expert Opin. Drug Metab. Toxicol. 2008; 4(5):619-627
  • Chrysostomou C., Di Filippo S., Manrique AM., Schmitt C., Orr R., Casta A., Suchoza E., Janosky J., Davis P., Munoz R. “Use of Dexmedetomidine in Children after Cardiac and Thoracic Surgery”  Pediatr Crit Care Med 2006; 7:126-131

    View Dr. Chrysostomou's full list of publications from PubMed.

Active Research Projects / Grants

  • A Phase II, Escalating Dose, Study to Determine the Pharmacokinetic and Pharmacodynamic Profile of Dexmedetomidine in Children 12 months - 24 months of age
  • A Phase II, Multicenter, Escalating Dose, Study to Determine Pharmacokinetic and Pharmacodynamic Profile of Dexmedetomidine in Premature (≥ 28 Weeks) and Full-term Neonates.
  • Therapeutic Use of Dexmedetomidine for the Termination of Supraventricular Tachycardia: A Randomized Control Study
  • Use of Dexmedetomidine for the Acute Treatment of Atrial Ectopic Tachycardia
  • Effects of Dexmedetomidine on Inflammatory Response after Cardiopulmonary Bypass in Children
  • Increased Survival after Pediatric Cardiac ECMO
  • Safety of Surfactant During ECMO
Last Update
July 20, 2011
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Last Update
July 20, 2011