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412-692-5930 Phone

412-692-5565 Fax

Job Title Chief, Pediatric Infectious Diseases

Job Title Professor of Pediatrics and Immunology, University of Pittsburgh School of Medicine

One Children's Hospital Drive
4401 Penn Ave., Suite Floor 9

Pittsburgh, PA 15224

412-692-5930 Phone

412-692-5565 Fax

Email toni.darville@chp.edu

Medical School:	1987 University of Arkansas for Medical Sciences, Little Rock, AR
Residency:	1990 University of Arkansas for Medical Sciences, Little Rock, AR
Fellowship:	1993 University of Arkansas for Medical Sciences, Little Rock, AR

Undergraduate

Graduate

Postgraduate/Fellowship

Chief Pediatric Resident, University of Arkansas for Medical Sciences, 1989-1990
First Annual Southern Society for Pediatric Research Travel Award, 1991
Pediatric Infectious Diseases Fellowship Award, Pediatric Infectious Diseases Society and Bristol-Myers Squibb

Assistant Professorship

Recipient of the Red Sash Award from the Senior Medical School Class, 93, 95, 96, 97, 98, 99
Pediatric Infectious Diseases Society Young Investigator Award, 1998
Best Doctors in America: Central Region, Woodward and White, 1998-1999

Associate Professorship

Professorship

O'Connell, CM, Ingalls, RR, Andrews Jr. CW, Scurlock AM and Darville T: Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. J. Immunol. 2007; 179(6): 4027-34.
Reeves DM, Nagarajan U, O'Connell C, Andrews Jr. CW, and Darville T: Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection. Antimicrobial Agents and Chemotherapy, 2007; 51, 2646-2648.
Welter-Stahl L, Ojcius DM, Viala J, Girardin S, Liu W, Delarbre C, Philpott D, Kelly KA, Darville T: Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum. Cell Microbiol, 2006 Jun 8; (6):1047-1057.

The ultimate goal of Dr. Darville's lab is to develop a vaccine to protect against chlamydial infection-induced sequelae of infertility and blindness, diseases of global societal and economic impact. The recent discovery of attenuated chlamydial strains has provided important tools useful for determining pathogen-specific virulence factors and host biomarkers of disease. In addition, studies indicate the attenuated chlamydial strains have strong potential as vaccine candidates.
Dr. Darville is actively examining innate immune receptors and signaling pathways stimulated by chlamydiae, and their role in generating a protective vs. pathogenic immune response. In vitro and animal model studies are used to determine signaling pathways important in the pathogenesis of disease due to Chlamydia trachomatis.
Dr. Darville's lab also has an interest in the role that chlamydial-induced host cell apoptosis plays in genital tract disease pathogenesis.
Dr. Darville is examining the role that novel cellular "danger signals" released from chlamydial infected cells, such as adenosine triphosphate (ATP) and high mobility group box 1 protein (HMGB1), have in the immune response and in disease pathogenesis.

May 1, 2009