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Physician Profile
412-692-8449
Phone
412-692-8299
Fax
David J. Hackam, MD, PhD
Job Title
Director, Training Program (START) for Medical
Job Title
Co-Director, Fetal Diagnosis and Treatment Center
Job Title
Assistant Professor of Surgery, University of Pittsburgh School of Medicine
Job Title
Assistant Professor Cell Biology and Physiology, University of Pittsburgh School of Medicine
45th St. & Penn Ave., Suite Floor 4
Pittsburgh,
PA
15201
412-692-8449
Phone
412-692-8299
Fax
Email
david.hackam@chp.edu
Education and Training
|
Medical School: |
1992 University of Western Ontario, London, Ontario, Canada |
|
Residency: |
2000 Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada |
|
Fellowship: |
2002 Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA |
Memberships
- American Society for Biochemistry and Molecular Biology
- American Academy of Pediatrics
- American College of Surgeons, Candidate Member
- Society of University Surgeons
- Shock Society
- American Association for the Advancement of Science
- American Gastroenterological Association
- Surgical Infection Society, Ad Hoc By-Laws Committee, Editoral Board
- American Society for Cell Biology
- Association for Academic Surgery, Active Member, Nominating Committee
- Canadian Medical Association
- Ontario Medical Association
- Alpha Omega Alpha Honor Medical Society
Board Certifications
- The American Board of Surgery, Pediatric Surgery
- The American Board of Surgery, General Surgery
- Royal College of Physicians and Surgeons of Canada
Awards
- Roberta Simmons Chair Honoree
- Watson Award Nominee, Alpha Omega Alpha Medical Society (Nominated by University of Pittsburgh medical students)
- Who's Who in Medical Sciences Education
- Exceptional Patient Satisfaction Award, Children's Hospital of Pittsburgh
- University of Pittsburgh School of Medicine, Excellence in Education Awards Nominee (Nominated by 1st & 2nd year medical students)
- Outstanding Surgeon Award, Critical Care Staff, Children's Hospital of Pittsburgh
- Outstanding Surgeon Award Nominee, Critical Care Staff, Children's Hospital of Pittsburgh
- First Prize - Oral Presentation, Canadian Association of Pediatric Surgeons
- William S. Fenwick Research Award, Faculty of Medicine, University of Toronto
- First Prize - Oral Presentation, University of Toronto Annual Assembly of General Surgeons
- Canadian Research Gold Medal for Specialty Residents in Surgery, Royal College of Physicians and Surgeons of Canada
- Davis and Geck Award (Basic science contribution by clinical researcher),
Canadian Association of General Surgeons - Andrew Sass-Kortsak Research Award (Nominated by all students/fellows),
Hospital for Sick Children Research Institute - Basic Science Research Award (Abstract), Eastern Student Research Forum
- Institute of Medical Science Research Award (Abstract), Eastern Student Research Forum at the University of Miami, University of Toronto
- Canadian Association of Pediatric Surgeons Resident Award, First Place - Oral Presentation at Annual Meeting
- American Society for Cell Biology Predoctoral Research Award, Basic Science Competition - Abstract
- Institute of Medical Science Scientific Day, First Prize - Basic Science Poster
- Gallie-Batemen Research Award, First Prize, Oral Presentation, University of Toronto
- Resident Research Award for Novel Research Design and Experimentation,
Physicians Services Incorporated, University of Toronto - University of Toronto Annual Assembly of General Surgeons, First Prize - Oral Presentation
- Surgical Infection Society Resident Award, First Prize - Oral Presentation
- Predoctoral Research Award, American Society of Cell Biology
- Medical Research Council of Canada Research Fellowship
- Resident Research Fellowship, Ethicon Society of University Surgeons
- Hospital for Sick Children Research Fellowship
- Province of Ontario Graduate Scholarship (Declined)
- Laidlaw Prize - Honorable Mention, Institute of Medical Science, Toronto, Ontario, Canada
- Gallie-Bateman Research Award, Honorable Mention, University of Toronto
- Honorable Mention for Basic Science, Eastern Student Research Forum
- Surgical Alumni Scholarship, University of Toronto
- Research Fellowship, Hospital for Sick Children
- Graduation Class of 1992, Ranked in the top ten, University of Western Ontario
- Dean's Honor Roll, Academic Excellence in Medical School
- Award of Academic Excellence, (Highest Mark in Undergraduate Cell Biology), University of Western Ontario
- Dean's Honor Roll, Academic Excellence in First Year Undergraduate Biology, University of Western Ontario
Publications
- Anand RJ, Dai S, Rippel C, Leaphart C, Qureshi F, Gribar SC, Kohler JW, Li J, Beer Stolz D, Sodhi C, Hackam DJ. Activated Macrophages Inhibit Enterocyte Gap Junctions via the Release of Nitric Oxide. Am J Physiol Gastrointest Liver Physiol. 2007 Nov 1; [Epub ahead of print]
- Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol. 2007 Oct 1;179(7):4808-20.
- Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ. One-dimensional elastic continuum model of enterocyte layer migration. Biophys J. 2007 Dec 1;93(11):3745-52. Epub 2007 Aug 17.
Research Interests
- To understand the mechanisms governing the migration of intestinal epithelial cells during conditions of intestinal inflammation, such as necrotizing enterocolitis, Crohn's disease and infection. This information will hopefully provide novel therapeutic targets for treating these disorders.
- To understand the mechanisms of phagocytosis of pathogens by macrophages in neonates during conditions of inflammation. This information will hopefully provide insights for enhancing the immune system during critical illness.
- Initiating a large review of all patients with congenital diaphragmatic hernia to determine the optimal timing and mode of surgical repair.
- Initiating a retrospective and prospective review of patients with tracheo-esophageal fistula to determine the factors influencing outcome in these patients.
- Retrospective review of patients who have sustained traumatic intestinal injuries, to determine the optimal diagnostic modality and to determine strategies to improve their outcome.
Active Research Projects / Grants
- TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitis
- Mechanisms of Epithelial Restitution in NEC
- Pathogenesis and Treatment of Necrotizing Enterocolitis
- A Novel Role for Enterocytes in the Maintenance of Gut Barrier Function: Phagocytosis
