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412-692-7280 Phone

412-692-6069 Fax

David J. Hackam, MD, PhD

Job Title Co-Director, Fetal Diagnosis and Treatment Center

Job Title Director, Training Program (START) for Medical

Job Title Dean for Medical Student Research, University of Pittsburgh School of Medicine

Job Title Professor of Surgery, University of Pittsburgh School of Medicine

Job Title Associate Professor of Cell Biology and Physiology, University of Pittsburgh School of Medicine

Division of Pediatric General & Thoracic Surgery

4401 Penn Avenue

Pittsburgh, PA 15224

412-692-7280 Phone

412-692-6069 Fax

Email david.hackam@chp.edu

Patient Appointment Information

Profile
Active Research Projects

Education and Training

Medical School:	1998 University of Toronto, Institute of Medical Science, Hospital for Sick Children, Toronto, Ontario, Canada 1992 University of Western Ontario, London, Ontario, Canada
Residency:	2000 Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
Fellowship:	2002 Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pa.

Memberships

American Society for Biochemistry and Molecular Biology
American Academy of Pediatrics
American College of Surgeons, Candidate Member
Society of University Surgeons, Treasurer
Shock Society
American Association for the Advancement of Science
American Gastroenterological Association
Surgical Infection Society, Ad Hoc By-Laws Committee, Editoral Board
American Society for Cell Biology
Association for Academic Surgery, Active Member, Nominating Committee
Canadian Medical Association
Ontario Medical Association
Alpha Omega Alpha Honor Medical Society
American Surgical Association

Board Certifications

The American Board of Surgery, Pediatric Surgery
The American Board of Surgery, General Surgery
Royal College of Physicians and Surgeons of Canada

Awards

Roberta Simmons Chair Honoree
Watson Award Nominee, Alpha Omega Alpha Medical Society (Nominated by University of Pittsburgh medical students)
Who's Who in Medical Sciences Education
Exceptional Patient Satisfaction Award, Children's Hospital of Pittsburgh
University of Pittsburgh School of Medicine, Excellence in Education Awards Nominee (Nominated by 1st & 2nd year medical students)
Outstanding Surgeon Award, Critical Care Staff, Children's Hospital of Pittsburgh
Outstanding Surgeon Award Nominee, Critical Care Staff, Children's Hospital of Pittsburgh
First Prize - Oral Presentation, Canadian Association of Pediatric Surgeons
William S. Fenwick Research Award, Faculty of Medicine, University of Toronto
First Prize - Oral Presentation, University of Toronto Annual Assembly of General Surgeons
Canadian Research Gold Medal for Specialty Residents in Surgery, Royal College of Physicians and Surgeons of Canada
Davis and Geck Award (Basic science contribution by clinical researcher),
Canadian Association of General Surgeons
Andrew Sass-Kortsak Research Award (Nominated by all students/fellows),
Hospital for Sick Children Research Institute
Basic Science Research Award (Abstract), Eastern Student Research Forum
Institute of Medical Science Research Award (Abstract), Eastern Student Research Forum at the University of Miami, University of Toronto
Canadian Association of Pediatric Surgeons Resident Award, First Place - Oral Presentation at Annual Meeting
American Society for Cell Biology Predoctoral Research Award, Basic Science Competition - Abstract
Institute of Medical Science Scientific Day, First Prize - Basic Science Poster
Gallie-Batemen Research Award, First Prize, Oral Presentation, University of Toronto
Resident Research Award for Novel Research Design and Experimentation,
Physicians Services Incorporated, University of Toronto
University of Toronto Annual Assembly of General Surgeons, First Prize - Oral Presentation
Surgical Infection Society Resident Award, First Prize - Oral Presentation
Predoctoral Research Award, American Society of Cell Biology
Medical Research Council of Canada Research Fellowship
Resident Research Fellowship, Ethicon Society of University Surgeons
Hospital for Sick Children Research Fellowship
Province of Ontario Graduate Scholarship (Declined)
Laidlaw Prize - Honorable Mention, Institute of Medical Science, Toronto, Ontario, Canada
Gallie-Bateman Research Award, Honorable Mention, University of Toronto
Honorable Mention for Basic Science, Eastern Student Research Forum
Surgical Alumni Scholarship, University of Toronto
Research Fellowship, Hospital for Sick Children
Graduation Class of 1992, Ranked in the top ten, University of Western Ontario
Dean's Honor Roll, Academic Excellence in Medical School
Award of Academic Excellence, (Highest Mark in Undergraduate Cell Biology), University of Western Ontario
Dean's Honor Roll, Academic Excellence in First Year Undergraduate Biology, University of Western Ontario
Watson Chair Honoree, University of Pittsburgh School of Medicine Department of Surgery
American Surgical Association, Elected member

Publications

Neal MD, Sodhi CP, Jia H, Dyer M, Egan C, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T, Grant Z, Ozolek J, Hackam DJ. Toll like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53-upregulated modulator of apoptosis. J Biol Chem. 2012 Sep 6. [Epub ahead of print]
Misty Good, Richard Siggers, Chhinder P. Sodhi, Amin Afrazi, Feras Alkhudari, Charlotte E. Egan, Matthew D. Neal, Ibrahim Yazji, Hongpeng Jia, Joyce Lin, Maria F. Branca, Congrong Ma, Thomas Prindle, Zachary Grant, Sapana Shah, Dennis Slagle II, Jose Paredes, John Ozolek, George Gittes, David J. Hackam. Amniotic Fluid Inhibits Toll Like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium. Proceedings of the National Academy of Sciences (PNAS). In Press 2012.
Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis. PLoS One. 2012;7(5):e365560. Epub 2012 May 17.

View Dr. Hackam's full list of publications from PubMed.

Research Interests

To understand the mechanisms governing the migration of intestinal epithelial cells during conditions of intestinal inflammation, such as necrotizing enterocolitis, Crohn's disease and infection. This information will hopefully provide novel therapeutic targets for treating these disorders.
To understand the mechanisms of phagocytosis of pathogens by macrophages in neonates during conditions of inflammation. This information will hopefully provide insights for enhancing the immune system during critical illness.
Initiating a large review of all patients with congenital diaphragmatic hernia to determine the optimal timing and mode of surgical repair.
Initiating a retrospective and prospective review of patients with tracheo-esophageal fistula to determine the factors influencing outcome in these patients.
Retrospective review of patients who have sustained traumatic intestinal injuries, to determine the optimal diagnostic modality and to determine strategies to improve their outcome.

Biography Summary

David J. Hackam, MD, PhD, is an attending pediatric surgeon in the Division of Pediatric General and Thoracic Surgery and co-director of the Fetal Diagnosis and Treatment Center of UPMC. At the University of PIttsburgh School of Medicine, he is professor of Surgery and in 2011, was named associate dean for Medical Student Research.

In his new role and working closely with faculty leaders, Dr. Hackam will promote excellence in medical research and education as one of his highest priorities. He will oversee the Scholarly Project, a longitudinal research project that each medical student participates in as a requirement for graduation. Dr. Hackam’s additional priorities will include enhancing the selection and training of research mentors and strengthening overall research opportunities for medical students within the medical school.

Dr. Hackam joined the University of Pittsburgh School of Medicine in the Department of Surgery as assistant professor in 2002. His research has been funded by the National Institutes of Health since 2002 and various other governmental agencies, and he collaborates with the pharmaceutical industry in order to bring novel potential therapeutics from the bench to the bedside. His research is focused on the role of the innate immune system in intestinal injury, repair and regeneration in understanding the pathogenesis of necrotizing enterocolitis.

Dr. Hackam completed his internship and residency in general surgery at Toronto General Hospital. He completed a clinical fellowship (2000-2002) in pediatric surgery at Children’s Hospital of Pittsburgh.

Active Research Projects / Grants

TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitis
Mechanisms of Epithelial Restitution in NEC
Pathogenesis and Treatment of Necrotizing Enterocolitis
A Novel Role for Enterocytes in the Maintenance of Gut Barrier Function: Phagocytosis

Last Update
December 11, 2012

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