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Jay Kolls, MD

Jay Kolls, MD
Job Title Director, Richard King Mellon Foundation Institute for Pediatric Research
Job Title Professor of Pediatrics and Immunology, University of Pittsburgh School of Medicine
Job Title Vice Chair for Translational Research
Job Title Interim NIH T32 Program Director, Division of Pediatric Rheumatology
4401 Penn Ave., Suite 8130 Rangos Research Center
Pittsburgh, PA 15224
412-692-7710 Phone
412-692-6184 Fax

Education and Training

Medical School:

1985 University of Maryland School of Medicine, Baltimore, MD
 

Residency:

1989 Louisiana State University Affiliated Hospitals, New Orleans, LA
 

Fellowship:

1993 Tulane University Medical Center, New Orleans, LA
 

Memberships

  • F1000 Immunology
  • Association of American Physicians
  • American Society of Clinical Investigation
  • Southern Society of Clinical Investigation
  • Society for Biological Therapy
  • American Society of Gene Therapy
  • American Association for the Advancement of Science
  • American Society of Microbiology
  • American Thoracic Society
  • American College of Chest Physicians
  • American College of Physicians, Associate
  • American Academy of Pediatrics, Candidate Fellow
  • Southern Medical Association
  • American Medical Associatio
  • Sigma Pi Sigma

Board Certifications

  • American Board of Pediatrics
  • American Board of Internal Medicine
  • Pulmonary Medicine 
  • Pediatric Pulmonology
  • FLEX
  • ACLS
  • PALS

Awards

  • 2013 Named in Pittsburgh Magazine’s “Best Doctors” list
  • 2006 Inaugural Chair, Neils K. Jerne Endowed Chair in Immunology, University of Pittsburgh
  • 1995, 1996, 1997 Recipient, American Federation of Clinical Research Young Faculty Award
  • 1994 Recipient, First Place, Merck Young Investigator Award, regional Southern Society of Clinical Investigation Meeting, New Orleans, Louisiana
  • 1993 Recipient, Second Place, Merck Young Investigator Award, regional Southern Society of Clinical Investigation Meeting, New Orleans, Louisiana
  • 1992 Recipient, First Prize, Louisiana State University Medicine Research Day
    1991 Recipient, Louisiana State University Neuroscience Research Award
  • 1991 Recipient, American Lung Association Pediatric Pulmonary Research Fellowship Award (declined)
  • 1991 Recipient, Parker B. Francis Pulmonary Research Fellowship Award
  • 1980 Sigma Pi Sigma, Physics Honor Society, Ursinus College

Publications

  • Chen K, McAleer JP, Lin Y, Paterson DL, Zheng M, Alcorn JF, Weaver CT, Kolls JK., Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity. 2011 Dec 23;35(6):997-1009.
  • Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK. IL-23 Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection. Infect Immun. 2011 Oct 24.
  • Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011;6(5):e20333.
  • Zheng M, Rapaka RR, Yu AC, Shellito JE, Kolls JK. Role of interleukin-23-dependent antifungal immune responses in dendritic cell-vaccinated mice. Infect Immun. 2011 Sep;79(9):3778-83.

Research Interests

The major goal of Dr. Kolls' research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts.  Presently, he is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung.  To this end, he studies cellular sources of IL-17A, IL-17F, and IL-22 in the lung and liver as well as their signaling in response to pulmonary infection or hepatitis. 
 
Dr. Kolls also has a long standing interest to determine if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis.  He also has a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer.  In these studies, he has identified that sub-populations of CD8+ T-cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii.  
 
Dr. Kolls is presently using gene expression profiling and proteomics to define this effector activity.  He also has a program in developing CD4-independent vaccination against AIDS-related opportunistic infections.

Active Research Projects / Grants

  • T cells in P. carinii Pneumonia
  • Non-CD4 Host Defense against P. carinii Pneumonia
  • Host Defense Against HIV-related Pulmonary Infections
  • Th17 Cytokines and Lung Host Defense
  • Host Factors in Fungal Allergy and Fibrosis
  • Project Leader, Alcohol Research Center, Project 3
  • Alcohol, ROS, and Macrophage Epigenetics
  • Novel Macrolide Th17 Inhibitors
  • Development of a novel PCP Vaccine for AIDS patients
Last Update
October 1, 2013
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Last Update
October 1, 2013
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