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Physician Profile

412-692-7710 Phone

412-692-6184 Fax

Jay Kolls, MD

Job Title Director, Richard King Mellon Foundation Institute for Pediatric Research

Job Title Professor of Pediatrics and Immunology, University of Pittsburgh School of Medicine

Job Title Vice Chair for Translational Research

Job Title Interim NIH T32 Program Director, Division of Pediatric Rheumatology

Richard King Mellon Foundation Institute for Pediatric Research

4401 Penn Ave., Suite 8130 Rangos Research Center

Pittsburgh, PA 15224

412-692-7710 Phone

412-692-6184 Fax

Email jay.kolls@chp.edu

Profile
Active Research Projects

Education and Training

Medical School:	1985 University of Maryland School of Medicine, Baltimore, MD
Residency:	1989 Louisiana State University Affiliated Hospitals, New Orleans, LA
Fellowship:	1993 Tulane University Medical Center, New Orleans, LA

Memberships

F1000 Immunology
Association of American Physicians
American Society of Clinical Investigation
Southern Society of Clinical Investigation
Society for Biological Therapy
American Society of Gene Therapy
American Association for the Advancement of Science
American Society of Microbiology
American Thoracic Society
American College of Chest Physicians
American College of Physicians, Associate
American Academy of Pediatrics, Candidate Fellow
Southern Medical Association
American Medical Associatio
Sigma Pi Sigma

Board Certifications

American Board of Pediatrics
American Board of Internal Medicine
Pulmonary Medicine
Pediatric Pulmonology
FLEX
ACLS
PALS

Awards

2006 Inaugural Chair, Neils K. Jerne Endowed Chair in Immunology, University of Pittsburgh
1995, 1996, 1997 Recipient, American Federation of Clinical Research Young Faculty Award
1994 Recipient, First Place, Merck Young Investigator Award, regional Southern Society of Clinical Investigation Meeting, New Orleans, Louisiana
1993 Recipient, Second Place, Merck Young Investigator Award, regional Southern Society of Clinical Investigation Meeting, New Orleans, Louisiana
1992 Recipient, First Prize, Louisiana State University Medicine Research Day
1991 Recipient, Louisiana State University Neuroscience Research Award
1991 Recipient, American Lung Association Pediatric Pulmonary Research Fellowship Award (declined)
1991 Recipient, Parker B. Francis Pulmonary Research Fellowship Award
1980 Sigma Pi Sigma, Physics Honor Society, Ursinus College

Publications

Chen K, McAleer JP, Lin Y, Paterson DL, Zheng M, Alcorn JF, Weaver CT, Kolls JK., Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity. 2011 Dec 23;35(6):997-1009.
Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK. IL-23 Mediated Inflammation in Pseudomonas aeruginosa Pulmonary Infection. Infect Immun. 2011 Oct 24.
Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011;6(5):e20333.
Zheng M, Rapaka RR, Yu AC, Shellito JE, Kolls JK. Role of interleukin-23-dependent antifungal immune responses in dendritic cell-vaccinated mice. Infect Immun. 2011 Sep;79(9):3778-83.

View Dr. Kolls' full list of publications from PubMed.

Research Interests

The major goal of Dr. Kolls' research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. Presently, he is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. To this end, he studies cellular sources of IL-17A, IL-17F, and IL-22 in the lung and liver as well as their signaling in response to pulmonary infection or hepatitis.

Dr. Kolls also has a long standing interest to determine if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis. He also has a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer. In these studies, he has identified that sub-populations of CD8+ T-cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii.

Dr. Kolls is presently using gene expression profiling and proteomics to define this effector activity. He also has a program in developing CD4-independent vaccination against AIDS-related opportunistic infections.