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412-692-5180 Phone
412-692-7355 Fax

Mark E. Lowe, MD, PhD

Job Title Chief, Division of Pediatric Gastroenterology
Job Title Professor of Pediatrics, University of Pittsburgh School of Medicine
4401 Penn Avenue, Suite Floor 3
Pittsburgh, PA 15224
412-692-5180 Phone
412-692-7355 Fax

Education and Training

Medical School:

1984 University of Miami, FL.


1986 St. Louis Children's Hospital, MO


1989 St. Louis Children's Hospital, MO

Board Certifications

  • American Board of Pediatrics
  • American Board of Pediatrics, Sub-Board of Pediatric Gastroenterology


  • D'Silva S, Xiao X, Lowe ME. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007 Nov;48(11):2478-84.
  • Whitcomb DC, Lowe ME. Human pancreatic digestive enzymes. Dig Dis Sci. 2007 Jan;52(1):1-17.
  • Kandula L, Khan S, Whitcomb DC, Lowe ME. Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link? JOP. 2006 Sep 10;7(5):482-5.

Research Interests

  • NIH RO1: Pancreatic lipases and colipase in lipolysis and obesity
  • NIH RO1: Structure-function of colipase and lipase
  • NIH RO1: Physiochemical enzyme regulation in enzyme metabolism

Biography Summary

Mark E. Lowe, MD, PhD, joined Children's Hospital of Pittsburgh in 2003 as chief of the Division of Pediatric Gastroenterology, bringing with him a National Institutes of Health-supported laboratory investigating the role of enzymes, called lipases, in the digestion of dietary fats. Dr. Lowe is also a visiting professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Lowe earned a bachelor's degree in biology at Washington University in St. Louis in 1973. Four years later, he earned a doctorate in biochemistry at the University of Pennsylvania. He spent the next five years at the National Institutes of Health as a staff fellow in biochemistry and in pediatric metabolism, and as a senior staff fellow in pediatric metabolism. Dr. Lowe earned his medical degree in 1984 at the University of Miami School of Medicine in Florida.

He was an intern, resident and fellow in pediatrics at St. Louis Children's Hospital. Before leaving St. Louis for Pittsburgh, he held several faculty positions at Washington University School of Medicine, including associate professor of pediatrics and associate professor of molecular biology and pharmacology. He is a member of several professional societies, including the American Gastroenterological Association and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Dr. Lowe's work has earned him the Mead Johnson Nutritionals Award from the American Society for Nutritional Sciences, the American Heart Association Established Investigator and several other honors.

Dr. Lowe's laboratory is investigating a number of issues involving lipases and their roles in digestion and disease. His work includes studying how Itmap 1, a membrane protein, behaves as a protective mechanism against pancreatitis. Dr. Lowe's lab is also engaged in basic science to gain a deeper understanding of the function of lipases and procolipase in newborns - knowledge important to finding better ways to feed chronically ill infants. In addition, his lab is developing evidence that suggests that enterostatin, a peptide, plays an influential role in regulating appetite and determining body weight set point.

Last Update
August 20, 2012
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Last Update
August 20, 2012