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412-648-3291 Phone
412-624-6666 Fax

Diana M. Metes, MD

Diana Metes
Job Title Associate Professor, Surgery and Immunology
4401 Penn Avenue, Suite Floor 3
Pittsburgh, PA 15224
412-648-3291 Phone
412-624-6666 Fax

Education and Training

Medical School:

1985 Faculty of General Medicine, Institute of Medicine and Pharmacy, Bucharest, Romania 


1991 Hematology, Institute of Hematology, Bucharest, Romania


1996 Immunology/Molecular Biology, Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pa.
1994 Immunology, Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pa.


  • The Transplantation Society 
  • American Society of Transplantation
  • American Association of Immunologists


  • 2009-2011 Roche Organ Transplantation Research Foundation Award
  • 2009 Selected lecturer for the “Vice Chancellor Seminar”, UPSOM, Pittsburgh, Pa.
  • 2003 Travel Award to the 3rd Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS) 2003 Paris, France
  • 2001-2002 Junior Faculty Research Award, Lymphoma Research Foundation of America
  • 2000 Young Investigator Award for the Transplant 2000 Meeting, American Society of Transplantation, Chicago, Ill.
  • 1996, 1997 University of Pittsburgh Cancer Institute, Director’s Award for scientific excellence and potential 2nd place, UPCI Scientific Retreat, Johnstown, Pa.
  • 1994-1995 Postdoctoral Fellowship, NCI, NIH
  • 1992-1994 Postdoctoral Fellowship, Fogarty Foundation, NIH
  • 1990 Romanian Society for Immunology: Award for Excellence in Immunology, 7th National Scientific Meeting, Cluj, Romania


  • Macedo C, Walters JT, Orkis EA, Elinoff BD, Fedorek SP, Chalasani G, Kumico , Demetris AJ, Zeevi A, Shapiro R, Lakkis FG, Metes D. Long-term effects of Alemtuzumab induction on regulatory and memory T cell subsets and their relationship to clinical outcome in kidney transplant recipients. Transplantation; 2012; 93(8):813-21. 
  • Wiesmayr S., Webber SA., Smith L., Popescu I., Macedo C., Metes D. Decreased NKp46 and NKG2D expression in the presence of elevated PD-1 lead to significant NK cell functional alterations in pediatric Tx patients with PTLD. European Journal of Immunology; 2012; 42:541-550.
  • Macedo C, Webber SA, Donnenberg A, Popescu I, Hua Y, Green M, Rowe D, Smith L, Brooks M, Metes D. EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function. Journal of Immunology; 2011; 186(10):5854-62.

Research Interests

  • Immune responses to EBV 
  • Cellular Immunotherapy for Post Transplant Lymphoproliferative Disorders (PTLD)
  • DC immunobiology in solid organ transplant recipients
  • Memory T cell responses in solid organ transplant patients

Active Research Projects / Grants

  • Chronic high EBV load and risk of PTLD in pediatric 
    heart transplant patients
  • T and B cell Homeostasis After Induction Therapy in Kidney Transplantation
  • Thomas E. Starzl Transplantation Institute-Human immunology Program
  • Interdisciplinary Training in Transplantation Biology
Last Update
February 9, 2013
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Last Update
February 9, 2013