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412-692-7816 Fax

Al-Walid A. Mohsen, PhD

Al-Walid A. Mohsen, PhD
Job Title Research Assistant Professor and Lab Supervisor, Department of Pediatrics, Division of Medical Genetics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh
4401 Penn Ave., Suite Floor 5
Pittsburgh, PA 15224
412-692-6498 Phone
412-692-7816 Fax

Education and Training

Undergraduate:

1982 Faculty of Science Ein-Shams University, Cairo
 

Graduate:

1992 Auburn University, Auburn, AL
 

Fellowship:

1995 Mayo Clinic, Rochester, MN

Memberships

  • American Society of Biochemistry and Molecular Biology

Awards

  • High Scholarship and Outstanding Achievement, Gamma Sigma Delta 
  • Outstanding Academic Achievement, Auburn University, AL

Research Interests

Recent
  • Luís, P. B.M., Ruiter, J. P.N., IJlst, L., de Almeida, I.T., Duran, M., Mohsen, A.-W. A., Vockley, J., Wanders, R.J.A., and Silva, M. F.B. (2011) Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase  in mitochondrial metabolism of valproic acid: Implications for the branched chain amino acid oxidation pathway. Drug Met. Disposition, accepted.
  • Homayoun, H., Khavandgar, S., Hoover, J. M., Mohsen, A.-W. A., Vockley, J., and Clemens, P.R. (2011) Novel mutation in MYH7 gene associated with distal myopathy and cardiomyopathy. Neuromuscular Disorders, accepted; available online.
  • He, M., Pei, Z., Majumder, N. , Mohsen, A.-W., Waltkins, P. , Murdoch, G., Van Veldhoven, P.P., Vockley, J. (2011) New acyl-CoA dehydrogenases: Redefining long chain fatty acid catabolism. Mol. Genet. Met. 102(4):418-29.
  • Wang, Y., Mohsen, A.-W. A., Mihalik, S. J., Goetzman, E., Vockley, J. (2010) Evidence for the physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes. J. Biol. Chem. 285(39):29834-41.
  • Alfardan, J., Mohsen, A.-W. A., Copeland, S., Ellison, J., Keppen-Davis, L., Rohrbach, M., Powell, B. R., Gillis, J., Matern, D., Kant, J., and Vockley, J. (2010). Characterization of new ACADSB gene sequence mutations and clinical implications in patients with 2-methylbutyrylglycinuria identified by newborn screening. Mol. Genet. Met. 100(4):333-8.
  • Maher, A, Mohsen, A.-W. A., Vockley, J, and Tarnopolsky, M. A. (2010). Low expression of long-chain acyl-CoA dehydrogenase in human skeletal muscle.  Mol. Genet. Met. 100(2):163-7.
Selected
  • Mohsen, A.-W. A., Rigby,  S.E., Jensen, K.F., Munro, A.W., and Scrutton, N.S.* (2004). Thermodynamic basis of electron transfer in dihydoorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR and ENDOR spectroscopy. Biochemistry, 43(21):6498-510.
  • Vockley, J.*, Mohsen, A-W. A., Binzak, B., Willard, J., and Fauq, A. (2000) Mammalian branched-chain Acyl-CoA Dehydrogenases: Molecular cloning and characterization of the recombinant enzymes. Methods Enzymol. 324:241-258.
  • Mohsen, A.-W. A., Anderson, B., Volchenboum, S. L., Battaile, K., Tiffany, K. A., Roberts, D. L.,  Kim, J.-J. P., and Vockley, J.* (1998). Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia. Biochemistry, 37:10325-35.
  • Mohsen, A.-W. A., and Vockley, J.* (1995). Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase. Biochemistry, 34:10146-52.
  • Mohsen, A.-W. A., and Vockley, J.* (1995). High-level expression of an altered cDNA encoding human isovaleryl-CoA dehydrogenase in Escherichia coli. Gene, 160:263-267.
  • Mohsen, A.-W. A., Aull, J. L., Payne, M., and Daron, H. H.* (1995). Ligand-induced conformational changes of thymidylate synthase.

Active Research Projects / Grants

  • NIH R21: Development of Chemical Chaperone for Medium Chain Acyl-CoA Dehydrogenase Deficiency, Principal Investigator
  • NIH R01: Molecular Characterization of Acyl-CoA Dehydrogenases, Co-Principal Investigator
  • Hyperion Therapeutics: Metabolism of Phenylbutyryl-CoA Through Fatty Acid Oxidation, Co-Principal Investigator
Last Update
April 7, 2011
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Last Update
April 7, 2011
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