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Physician Profile
412-692-5930
Phone
412-692-5565
Fax
Catherine O'Connell, PhD
Job Title
Assistant Professor of Pediatrics, University of Pittsburgh School of Medicine
One Children's Hospital Drive
4401 Penn Ave., Suite Floor 9
Pittsburgh,
PA
15224
4401 Penn Ave., Suite Floor 9
412-692-5930
Phone
412-692-5565
Fax
Education and Training
|
Graduate School: |
1993 Dublin University (Trinity College), Dublin, Ireland |
|
Postgraduate: |
1996 Uniformed Services, University of the Health Sciences, Bethesda, MD |
Memberships
- American Society for Microbiology
Awards
- F. S. Stewart Prize (Microbiology)Phi Beta Kappa
- Trinity Trust Pre-doctoral Fellowship
- Wellcome Trust Research Assistantship
Publications
- Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease.
O'Connell CM, Ingalls RR, Andrews CW, Scurlock AM, Darville T
J Immunol. 2007; 179(6): 4027-34. - O'Connell CM, Nicks KM. A plasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture. Microbiology. 2006 Jun;152(Pt 6):1601-7.
- O'Connell CM, Ionova IA, Quayle AJ, Visintin A, Ingalls RR. Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen. J Biol Chem. 2006 Jan 20;281(3):1652-9. Epub 2005 Nov 17.
Research Interests
- Development of genetic tools for analysis of chlamydial pathogenesis
- Characterization of the role played by the chlamydial "cryptic plasmid" in virulence
- Development of a live attenuated vaccine against chlamydial disease
Active Research Projects / Grants
- Cell death and innate immunity in chlamydial infection
