Research

Origins of Insulin Resistance

Fetal Origins of Childhood Insulin Resistance and Risk for Type 2 Diabetes, Hyperandrogenism and Cardiovascular Disease

Protocol Description

This study is being conducted to see if insulin resistance, which is associated with many adult diseases, has its origins before a child is born. Such adult diseases include Type-2 diabetes, high blood pressure, elevated cholesterol, cardiovascular disease and, in girls, polycystic ovary syndrome. To answer these research questions, Children’s Hospital of Pittsburgh of UPMC is evaluating growth and metabolic profile of children whose mothers participated in the Prenatal Exposure and Preeclampsia Prevention (PEPP) study at Magee-Womens Hospital of UPMC.

Eligibility Criteria

Children of either sex whose mothers participated in the PEPP study are eligible for the initial screening process, which includes a qualifying physical examination.
Boys: 8 to 18 years
Girls: 8 to 18 years

Requirements
Those who qualify based on the initial screening process will have a second visit, conducted at the Pediatric Clinical and Translational Research Center (PCTRC), in which outpatient tests will be performed to evaluate glucose and insulin response to sugar load and evaluation of body composition.
Visits: 2
Duration: None beyond second visit

Status: Open for Enrollment

Source of Support
Children’s Hospital of Pittsburgh of UPMC