Research

Retinoblastoma Genetic Analysis

Carcinogen Metabolism, DNA Repair, Parental Exposures and Retinoblastoma

Protocol Description

The main goal of this Children’s Oncology Group observational study is to understand how genes and environmental exposures affect a child’s chances of developing retinoblastoma, a cancer of the eye. To do this researchers will compare the exposures and genes of children with unilateral (one eye) or bilateral (both eyes) retinoblastoma to that of children who do not have retinoblastoma.

Eligibility Criteria

Subject to certain exclusion criteria, children of both genders who have been diagnosed with sporadic retinoblastoma on or after 07/01/2006.
Males: All ages
Females: All ages

Requirements
Researchers will conduct a telephone interview about health and medical history with parents and collect blood or saliva samples from both the child and parents. Alternately, saliva samples may be collected. If the child had or will have surgery to remove the tumor and there is leftover tissue from surgery, researchers will analyze the tumor DNA for certain gene mutations.
Visits: Not applicable
Duration: Genetic analysis may take up to 1 year, but can be shared with the participant’s physician, if desired by the parents.

Status: Open for Enrollment

Source(s) of Support
Children’s Oncology Group (Study AEPI05N1)
National Cancer Institute

Additional Resources
Study Description at National Institutes of Health