Research

Search for a Cause of Diabetes

Etiology and Epidemiology of Insulin Dependent Diabetes

Protocol Description

Now entering its 30th year, this groundbreaking, long-term study explores the causes of type 1 diabetes, with the objectives of aiding in the cure and prevention of the disease. Through this study, researchers analyze the relationships between influential factors, such as viral infections, genetics and environment; obesity and related insulin resistance; and the importance of activation of white blood cells and various diabetes-related autoantibodies and what causes them to appear. The study compares new onset diabetes patients with their first-degree relatives. It continuously screens family members for diabetes-related immune factors, which can result in early intervention to help in the treatment of diabetes. Family members with high-risk antibodies may be eligible for ongoing trials aimed to prevent diabetes.

Eligibility Criteria

Participants include patients age 1 and up, who have Type 1 diabetes, as well as their family members.
Males: Age 1 and older
Females: Age 1 and older

Requirements
An interview, body measurements and a blood sample will be collected from participating patients and family members during initial screening and every 6 months.
Visits: 2 times a year
Duration: 2 years for participating children with diabetes and 10 years for family members

Status: Closed to Enrollment

Source of Support
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases