Research

Regulation of Fatty Acid Oxidation in Adipose Tissues

This 3-year project seeks to understand the mechanisms regulating fatty acid oxidation in adipose tissues using mouse models and in vitro systems. A K01 Grant supported project (Mentored Scientist Development Award), it has recently focused on regulation of fatty acid oxidation by post-translational modifications, most notably reversible lysine acetylation.

This research has established that lysine acetylation regulates the activity of the key fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD).

Future plans include determining the mechanism by which acetylation alters LCAD enzymatic activity and how lysine acetylation may contribute to the pathogenesis of diseases such as obesity and diabetes.

Source(s) of Support
National Institute of Diabetes and Digestive and Kidney Diseases

Principal Investigator
Eric Goetzman, PhD

Last Update
August 14, 2010
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Last Update
August 14, 2010
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