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For more information about research, please call our main office at 412-692-6438.
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Some of the many Cancer and Blood Disorders research opportunities available related to cancers of the brain and central nervous system (CNS) are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is provided at the end of each study.
Please note that Pilot and Phase I studies are the most experimental and should be considered only after other treatments or trials have been attempted without success.
Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.
Clinical Studies
Researchers
ACNS1123: Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors
PBTC-045: Trial of MK-3475 in Children with Recurrent, Progressive, or Refractory Diffuse Intrinsic Pontine Glioma, Non-brainstem High-grade Gliomas, Ependymoma, Medulloblastoma, or Hypermutated Brain Tumors
PBTC-051: Study to Evaluate the Safety and Tolerability of the CD40 Agonistic Monoclonal Antibody APX005M in Pediatric Subjects with Recurrent/Refractory Brain Tumors and Newly Diagnosed Brain Stem Glioma
ACNS2021: A Study of a New Way to Treat Children and Young Adults with a Brain Tumor Called NGGCT
PBTC-049: Study of Savolitinib in Recurrent, Progressive, or Refractory Medulloblastoma, High-Grade Glioma, or Diffuse Intrinsic Pontine Glioma
ALTE05N1: Umbrella Long-Term Follow-Up Protocol for Participants with and without a History of Cancer
ALTE03N1: Key Adverse Events Following Childhood Cancer
APEC14B1: Project:Every Child, A Registry, Eligibility Screening, Biology and Outcome Study
PBTC-047: Panobinostat in Children with Diffuse Intrinsic Pontine Glioma
ACNS0831: Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma
Treatment for Recurrent Ependymomas in Children Using HLA-A2 Restricted Tumor Antigen Peptides in Combination With Imiquimod
ALTE2031: StepByStep: A Trial of a Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors
ALTE1631: A Web-based Physical Activity Intervention among Children and Adolescents
ACNS1931: A Study to Compare Treatment with the Drug Selumetinib Alone versus Selumetinib and Vinblastine in Patients with Recurrent or Progressive Low-Grade Glioma
ACNS1821: A Study of the Drug Selinexor with Radiation Therapy in Patients with Newly Diagnosed DIPG and High-Grade Glioma
ACNS1723: A Study of the Drugs Dabrafenib and Trametinib after Radiation Therapy in Patients with Newly Diagnosed High-Grade Glioma
ACNS1833: A Study of the Drugs Selumetinib vs. Carboplatin/Vincristine in Patients with Low-Grade Glioma
Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Recurrent Unresectable Low-Grade Gliomas (LGG)
PBTC-029B: Study of AZD6244 for Recurrent or Refractory Pediatric Low-Grade Glioma
ACNS0322: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
ACNS1422: A Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
ACNS0332: Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients
ACNS1831: A Study of the Drugs Selumetinib versus Carboplatin/Vincristine in Patients with Neurofibromatosis and Low-Grade Glioma
ACNS02B3: A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Specimens Including Rare Pediatric Tumors
ACNS1022: Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
PBTC-053: Surgical Study of CX-4945 in Patients with Recurrent SHH Medulloblastoma
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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