Research

Understanding How the Host Senses and Responds to Stress and Injury in the Pathogenesis of Necrotizing Enterocolitis

It has long been known that the host must identify the presence of cellular damage, and mount an effective response to this damage. Perturbations in either the sensing or the response to cellular injury has been shown to underlie a variety of inflammatory disorders including inflammatory bowel disease and necrotizing enterocolitis. One of the earliest effects of inflammatory stress involves a dramatic inability of adjacent cells within the intestinal mucosa to communicate with each other through a loss of gap junction proteins. We now seek to define the mechanisms by which cell-cell communication within the intestinal mucosa regulates the injury and repair mechanisms that underlie the development of NEC and other diseases.
 
Gastroenterology, March, 2007 (abstract)
 
 
Last Update
January 27, 2011
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Last Update
January 27, 2011
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