Research

The Role of the Innate Immune System in the Pathogenesis of Necrotizing Enterocolitis

This project focuses on the molecular and cellular determinants of necrotizing enterocolitis, in particular the role of the innate immune receptors (TLRs, NLRs) in the pathogenesis of NEC and their affects on mucosal injury and repair. The published papers shown below have more details about the ongoing work.
 
A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair
The Journal of Immunology, 2007 (full article)
 
Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis
Gastroenterology, January 2010 (abstract)
Last Update
January 27, 2011
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Last Update
January 27, 2011
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