Research

Recent Publications

David J. Hackam, MD, PhD and his team have authored numerous papers for publication in a wide range of national and international medical journals, reflecting the importance of their work in the research lab. Below are some of the most significant recent articles.

2013

Discovery and Validation of a New Class of Small Molecule Toll Like Receptor 4 (TLR4) Inhibitors
Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ
PLoS One
2013 Jun 12

Endothelial TLR4 Activation Impairs Intestinal Microcirculatory Perfusion in Necrotizing Enterocolitis via eNOS-NO-nitrite Signaling
Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ
Proc Natl Acad Sci U S A
2013 Jun 4

Mechanisms of Gut Barrier Failure in the Pathogenesis of Necrotizing Enterocolitis: Toll Like Receptors Throw The Switch
Hackam DJ, Good M, Sodhi CP
Seminars in Pediatric Surgery
2013 May

A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis
Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ
J Immunology
2013 Apr 1

Using a Continuum Model to Predict Closure Time of Gaps in Intestinal Epithelial Cell Layers
Arciero JC, Mi Q, Branca M, Hackam D, Swigon D
Wound Repair Regen
2013 Mar-Apr

Modeling the Interactions of Bacteria and Toll-like Receptor-mediated Inflammation in Necrotizing Enterocolitis
Arciero J, Bard Ermentrout G, Siggers R, Afrazi A, Hackam D, Vodovotz Y, Rubin J
J Theor Biol
2013 Mar 21

Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis
Hackam DJ, Afrazi A, Good M, Sodhi CP
Clin Dev Immunol
2013

2012

Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis
Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ
J Biol Chem
2012 Oct 26

WNT1-Inducible Signaling Pathway Protein 1 Contributes to Ventilator-Induced Lung Injury
Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder Sodhi, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM
Am J Respir Cell Mol Biol
2012 Oct

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and is Required for Necrotizing Enterocolitis in Mice
Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ
Gastroenterology
2012 Sep

Amniotic Fluid Inhibits Toll-like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium
Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK,Hackam DJ
Proc Natl Acad Sci U S A
2012 Jul 10

WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Contributes to Ventilator-Induced Lung Injury
Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM
Am J Respir Cell Mol Biol
2012 Jun 21

Novel Role for the Innate Immune Receptor Toll-like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis
Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS
PLoS One
2012 May 17

Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium
Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ
J Immunol
2012 May 1

2010

Intestinal Stem Cells and their Roles During Mucosal Injury and Repair
Neal MD, Richardson WM, Sodhi CP, Russo A, Hackam DJ
J Surg Res
2010 May 21

Nucleotide-binding Oligomerization Domain-2 Inhibits Toll Like Receptor-4 Signaling in the Intestinal Epithelium
Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, Branca M, Ma C, Ozolek J, Hackam DJ
Gastroenterology
2010 May 21

Extracellular High Mobility Group Box-1 (HMGB1) Inhibits Enterocyte Migration via Activation of Toll-like Receptor-4 and Increased Cell-matrix Adhesiveness
Dai S, Sodhi C, Cetin S, Richardson W, Branca M, Neal MD, Prindle T, Ma C, Shapiro RA, Li B, Wang JH, Hackam DJ
J Biol Chem
2010 Feb 12

2009

Toll-like-Receptor-4 Inhibits Enterocyte Proliferation via Impaired Beta-catenin Signaling in Necrotizing Enterocolitis
Sodhi CP, Shi XH, Richardson WM, Grant ZS, Shapiro RA, Prindle T Jr, Branca M, Russo A, Gribar SC, Ma C, Hackam DJ
Gastroenterology
2009 Sep 25

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis
Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ
J Immunol
2009 Jan 1

2008

A Role for Connexin43 in Macrophage Phagocytosis and Host Survival After Bacterial Peritoneal Infection
Anand RJ, Dai S, Gribar SC, Richardson W, Kohler JW, Hoffman RA, Branca MF, Li J, Shi XH, Sodhi CP, Hackam DJ
Immunol
2008 Dec 15

The Development of Animal Models for the Study of Necrotizing Enterocolitis
Sodhi C, Richardson W, Gribar S, Hackam DJ
Dis Model Mech.
2008 Sep-Oct

Interferon-gamma Inhibits Enterocyte Migration by Reversibly Displacing Connexin43 from Lipid Rafts
Leaphart CL, Dai S, Gribar SC, Richardson W, Ozolek J, Shi XH, Bruns JR, Branca M, Li J, Weisz OA, Sodhi C, Hackam DJ
Am J Physiol Gastrointest Liver Physiol
2008 Sep

No Longer an Innocent Bystander: Epithelial Toll-like Receptor Signaling in the Development of Mucosal Inflammation
Gribar SC, Richardson WM, Sodhi CP, Hackam DJ
Mol Med
2008 Sep-Oct

Increased Expression and Internalization of the Endotoxin Coreceptor CD14 in Enterocytes Occur as an Early Event in the Development of Experimental Necrotizing Enterocolitis
Mollen KP, Gribar SC, Anand RJ, Kaczorowski DJ, Kohler JW, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ
J Pediatr Surg
2008 June

The Role of Epithelial Toll-like Receptor Signaling in the Pathogenesis of Iintestinal Inflammation
Gribar SC, Anand RJ, Sodhi CP, Hackam DJ
J Leukoc Biol
2008 Mar

Activated Macrophages Inhibit Enterocyte Gap Junctions via the Release of Nitric Oxide
Anand RJ, Dai S, Rippel C, Leaphart C, Qureshi F, Gribar SC, Kohler JW, Li J, Stolz DB, Sodhi C, Hackam DJ
Am J Physiol Gastrointest Liver Physiol
2008 Jan

2007

A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair
Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ
J Immunol
2007 Oct 1

One-dimensional Elastic Continuum Model of Enterocyte Layer Migration
Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ
Biophys J
2007 Dec 1

Hypoxia Causes an Increase in Phagocytosis by Macrophages in a HIF-1alpha-dependent Manner
Anand RJ, Gribar SC, Li J, Kohler JW, Branca MF, Dubowski T, Sodhi CP, Hackam DJ
J Leukoc Biol
2007 Nov

Interferon-gamma Inhibits Intestinal Restitution by Preventing Gap Junction Communication Between Enterocytes
Leaphart CL, Qureshi F, Cetin S, Li J, Dubowski T, Baty C, Beer-Stolz D, Guo F, Murray SA, Hackam DJ
Gastroenterology
2007 June.

Toll-like Receptor-4 Plays a Role in Macrophage Phagocytosis During Peritoneal Sepsis
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ
J Pediatr Surg
2007 June

Nitric Oxide Inhibits Enterocyte Migration Through Activation of RhoA-GTPase in a SHP-2-dependent Manner
Cetin S, Leaphart CL, Li J, Ischenko I, Hayman M, Upperman J, Zamora R, Watkins S, Ford HR, Wang J, Hackam DJ
Am J Physiol Gastrointest Liver Physiol
2007 May

The Role of the Intestinal Barrier in the Pathogenesis of Necrotizing Enterocolitis
Anand RJ, Leaphart CL, Mollen KP, Hackam DJ.
Shock
2007 Feb

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Last Update
November 4, 2013
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Last Update
November 4, 2013
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