Inflammatory Bowel Disease and Biopsychosocial Effects

Understanding the Biopsychosocial Underpinnings of Abdominal Pain in Inflammatory Bowel Disease

Protocol Description

This 2-phase research study is designed to help researchers better understand factors related to abdominal pain in: (1) Crohn’s disease, a condition in which the body’s immune system does not work properly; and (2) Rome III childhood functional abdominal pain, which is characterized as pain without known medical cause. Researchers are interested in learning about how abdominal pain is affected by disease activity (for those with Crohn’s disease), psychological factors, sleep quality and stress. Researchers are also interested in finding ways to treat abdominal pain in pediatric patients.

Eligibility Criteria

Patients of both genders, ages 9 through 18, who are being seen at Children’s Hospital of Pittsburgh of UPMC for either Crohn’s disease or Rome III Childhood Functional Abdominal Pain, are eligible for inclusion.
Boys: Ages 9 through 18
Girls: Ages 9 through 18

At enrollment, participants will complete questionnaires relating to the nature of abdominal pain, presence or absence of depression and anxiety, and quality of life. Bloodwork and other sampling will be done, and parent questionnaires will be completed. Crohn’s patients will then be selected to either continue with standard medical care or be supplemented with a behavioral intervention, called cognitive-behavioral therapy (CBT) to help alleviate abdominal pain. Those with Rome III pain will also use CBT, which will be taught to both groups by a mental health professional, via 8 to 10 weekly sessions over the first 3 months, and 4 maintenance sessions in the next 3 months. CBT will focus on developing a variety of new skills to handle pain.
Visits: Up to 10
Duration: 6 months

Status: Open for Enrollment

Source of Support
Crohn’s and Colitis Foundation of America

Primary Investigator(s)

Arvind Srinath, MD

Contact Information

For more information about the study or enrollment, please contact:
David M. Rizzo, LCSW

Last Update
June 13, 2014
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Last Update
June 13, 2014