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One of the key missions of the Division of Pediatric Nephrology of UPMC Children’s Hospital of Pittsburgh is to extend the knowledge of pathophysiology of renal disease through basic laboratory and clinical research.
Key nephrology research includes an investigative focus on nephropathy in type 1 diabetes and in pediatric renal transplantation outcomes. Other areas of interest to Children’s researchers include proteinuria, hypertension, tubulointerstitial nephritis and dysnatremias.
Ongoing extramural grants support the investigation of the genetic epidemiology of urinary tract abnormalities and of the genetic aspects of nephrotic syndrome and of focal glomerulosclerosis. These are all common and important disorders in children. In addition Children’s researchers are conducting a biomarker-based study of BK virus, a polyoma virus, as it relates to renal allograft injury after renal transplantation in childhood.
Other nephrology research involves a study of the basic mechanisms of apoptosis in proximal tubular epithelial cells exposed to albumin to mimic the effect of proteinuric disorders in general.
Additionally, a cutting-edge research study is being done on trafficking of the cystic fibrosis transmembrane regulator (CFTR) as it relates to chloride transport in renal epithelial cells. Another important study is investigating trafficking of nephrin in the glomerular basement membrane, an important structural protein that normally protects against proteinuria and nephrotic syndrome.
Researchers
Clinical Studies
Study to Evaluate the Pharmacodynamic Effects, Safety, and Tolerability of Patiromer for Oral Suspension in Children and Adolescents 2 to
Study to Assess the Safety and Efficacy of Hectorol® (doxercalciferol capsules) in Pediatric Patients with Chronic Kidney Disease Stages 3 and 4 with Secondary Hyperparathyroidism Not Yet on Dialysis
Effect of LDL-Apheresis on Cardiovascular and Renal Outcomes in Focal Segmental Glomerulosclerosis
A Study of the Prevalence of Apolipoprotein L1 (APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin
The Effects of Sparsentan, a Dual Endothelin Receptor and Angiotensin Receptor Blocker, on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis
A 2-Part Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX‐147 in Adults with APOL1-mediated Focal Segmental Glomerulosclerosis
Cure Glomerulonephropathy
Study to Evaluate the Efficacy, Safety, and Tolerability of DCR-PHXC Solution for Injection in Patients with Primary Hyperoxaluria
Utilization of dd-cfDNA to Assess for Rejection
Rannar Airik, PhD Sunder Sims-Lucas, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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