Research

Pediatric Acute Liver Failure and Neurocognitive Function

Neurocognitive Function and Health-Related Quality of Life in Pediatric Survivors of Acute Liver Failure

Protocol Description

The purpose of this research study is to determine whether pediatric acute liver failure (PALF) patients differ from healthy children in neurobehavioral matters, including intellectual reasoning, attention/executive functioning, motor skills and mood. Some studies suggest that children with serious liver disease may be at higher risk for neurobehavioral problems that could potentially impact their academic success and independent functioning. Gaining a more complete understanding of the neurobehavioral risks PALF patients face could allow the development of interventions to address these risks and to optimize the quality of life for patients and their families.

Eligibility Criteria

Subject to certain exclusion criteria, boys and girls of all ages who were hospitalized with PALF and participated in a research study called “Pediatric Acute Liver Failure Study Group Registry and Biological Samples” are eligible.
Boys: Ages 3 through 17 years
Girls: Ages 3 through 17 years

Requirements
Researchers will conduct a single 3-hour neurobehavioral assessment at the Child Development Unit in Lawrenceville. Medical history information will also be collected, and the child’s teacher will also be asked to answer a 10-minute questionnaire about the child’s problem-solving skills.
Visits: 1
Duration: Not applicable

Status: Open to Enrollment to Patients Participating in the PALF Study Group Registry

Source of Support
National Institute of Diabetes and Digestive and Kidney Diseases