Research

Understanding Phase I Cancer Studies

Research Nurse Angie Krol along with Kim Ritchey, MD, and Regina Jakacki, MD, are key members of the Children's research team, all of whom are acutely tuned to the needs of patients and families engaged in Phase I cancer studies.
 

Children’s Hospital of Pittsburgh of UPMC is one of only 21 hospitals qualified to be part of the Children’s Oncology Group’s elite Phase I/Pilot Research Consortium.

Phase I drug studies are the most experimental in nature, and therefore are conducted with the smallest groups of volunteers. They are initiated after drugs have passed animal and cell studies, and are offered to those children for whom standard care and other clinical studies have already failed. Although Phase I experimental therapeutics present hope for such situations, as with any experimental treatment, there are no guarantees.

Quality of life, especially at this stage of treatment, is a top priority for Children’s medical and research team members, who are acutely tuned to the needs of patients and their families. Families who come from outside the Greater Pittsburgh region may incur travel costs. For Phase I studies in particular, Children’s can help through support it receives from Alex’s Lemonade Stand Foundation. Lodging for family members may be provided through the Ronald McDonald House.

Children’s studies in hematology and oncology are organized according to the seven groups listed below, and Pilot and Phase I clinical trials are labeled within each grouping for easy identification.

Brain and CNS Cancers
Leukemia
Lymphoma
Neuroblastomas
Rare Cancers and Blood Disorders
Tumors/Non-Sarcoma
Tumors/Sarcoma

Simply select a category and then browse the studies within the category to review brief descriptions and requirements. Physicians or parents/guardians of pediatric patients who might be eligible are encouraged to inquire about enrollment. Contact information is listed at the end of each study.

Last Update
March 1, 2012
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Last Update
March 1, 2012
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