Conditions We Focus On

Challenges addressed by the center

Complex Problems Requiring Novel Solutions

The initial work of the Center is focused on four specific challenges summarized below. Although these are high-risk pursuits, we are excited by the opportunity to create pathways to healthy outcomes where presently none exist.

Identification of Novel Treatments for Necrotizing Enterocolitis
Using specialized drug discovery methods, we are identifying new molecules that have the ability to decrease the amount of inflammation in the intestine in models of necrotizing enterocolitis. These reagents include natural products that are found in breast milk and amniotic fluid, as well as synthetic compounds.

Generation of an Artificial Intestine for Short Bowel and Other Conditions
Using a novel scaffold with the dimensional and biochemical properties that resemble the human intestine, our goal is to grow intestinal stem cells derived from a patient’s own body in order to generate a functional and viable artificial intestine. This would be used to treat short bowel syndrome, severe inflammatory bowel disease, or other severe intestinal conditions.

Novel Therapies for Sepsis in Children
Sepsis is associated with a reduction in blood flow to the major organs in the body which leads to organ shut down, and ultimately, to the death of the patient in severe cases. We are using novel approaches to determine methods to increase blood flow to the organs, in order to improve survival in these extremely ill patients.

Defining the Mechanisms that Underlie Traumatic Brain Injury in Children
Children that sustain brain injury develop areas of the brain in which high levels of chemical are released that cause local inflammation and tissue damage. We are seeking to limit the degree of brain injury by attenuating the release of these chemicals, and in so doing, to improve the outcome of these injured children.

Last Update
July 19, 2013
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Last Update
July 19, 2013