Research

Transplant Program Research

As a leader in pediatric health care and the world’s premier center for pediatric transplantation, Children’s Hospital of Pittsburgh of UPMC’s Transplant Program is dedicated to transforming lives through research and scientific study. With research support from government agencies, insurers and the community, Children’s Hospital continues to improve the medical management of pediatric transplant patients and, consequently, increase survival rates for all pediatric transplant patients.

Children’s research programs and clinical trials are helping to advance pediatric transplantation, with special focus on immunotherapy, transplantation tolerance, organ preservation, bioengineering, living intestine transplants and post-transplant therapies, including the reduction of steroid-based and immunosuppressive drugs.

The Pediatric Transplant Research Laboratory is developing ways to improve the effectiveness of anti-rejection medicines so that each child can receive the most appropriate at a dose that prevents rejection, but without side effects.

A research team at the Thomas E. Starzl Transplantation Institute is studying specific biological factors that may enable some patients to be successfully weaned from all immunosuppressive therapy. When precise clinical markers can be determined, it may be possible to develop simple tests that could help predict transplant tolerance.

Through ground-breaking research and advanced training programs, Children’s has developed innovative therapies for previously fatal liver and intestinal disorders. Patients of Children’s pediatric intestinal transplant program represent the world’s first and most successful series of small intestine transplants. Children’s also offers pediatric living-related liver transplants as a lifesaving alternative to the national cadaver organ shortage.

Clinical Team

Director, Pediatric Blood and Marrow Transplant
Rakesh K. Goyal, MD

Medical Director, Pediatric Cardiopulmonary Transplant Program
Steven A. Webber, MBChB

Medical Director, Pediatric Kidney Transplant Program
Demetrius Ellis, MD

Director, Pediatric Liver and Intestine Transplant Program
George Mazariegos, MD

Pediatric Transplant Research Laboratory

Last Update
September 20, 2012
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Last Update
September 20, 2012
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