Research

Urinary Tract Infection Biomarkers

Biomarkers for Urinary Tract Infection

Protocol Description

View an overview of the UTI Biomarkers study by Nader Shaikh, MD.

The purpose of this study is to determine whether a urinary tract infection (UTI) is in the bladder or the kidney by looking for proteins in the urine and genetic markers in the blood. That information will help doctors understand UTIs with a goal of determining better treatment strategies, such as how many days children should take antibiotics and whether they need further tests. This is an observational study, and participants’ UTI will be treated by their own doctors using standard methods of care.

Eligibility Criteria

Subject to certain exclusion criteria, this study is open to children of both genders who have been diagnosed with their first UTI.
Boys and Girls: At least 2 months of age but less than 11 years old

Requirements
In the initial visit parents will provide the child’s medical history and family history related to UTI and kidney disease, along with other relevant information. A limited physical examination will be done and urine and blood samples will be collected. Within 2 weeks, participants will also have a DMSA kidney scan to see if there is infection or scarring in the kidney. Researchers will share the results of the DMSA scan with the child’s doctor.
Visits: 2
Duration: 2 weeks

Status: Open for Enrollment

Source of Support
Research Advisory Committee of Children’s Hospital of Pittsburgh of UPMC
National Institutes of Health

Additional Resources
DMSA Renal (Kidney) Scan