Children's Hospital is part of the UPMC family.
This collaborative study by the Childhood Liver Disease Research Network (ChiLDReN) builds a prospective database with demographic and clinical information about infants with cholestatic disease and their families. The database provides a means of prospectively following this group over time to characterize the natural history of the disease and to identify environmental, infectious and genetic risk factors related to onset, outcome and treatment success for the different cholestatic diseases, with special emphasis on biliary atresia. The study also maintains repositories for blood, urine, bile and tissue samples from these children and blood samples from their biological parents for future research studies on liver diseases.
Infants no older than 6 months, with a diagnosis of clinically meaningful cholestasis due to primary hepatobiliary disease.
Boys and Girls: Newborn through 180 days
Participants will have a series of visits for physical examinations that will include collection of blood and urine samples, as would normally be done through routine clinic visits for patients with cholestasis. Visits generally are scheduled at 1, 2, 3 and 6 months following diagnosis and at 12, 18 and 24 months of age, and then annually until age 15. Information regarding the patient’s medical history and health care provider visits, prescribed medications, and diet will be obtained at each visit through personal interview.
Duration: 15 years
National Institute of Diabetes and Digestive and Kidney Diseases
Study Description at National Institutes of Health
Childhood Liver Disease Research Network
Robert H. Squires, MD
For more information about the study or enrollment, please contact:
Lori Haberstroh, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.