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Miguel Reyes-Múgica, MD

Job Title Chief of Pathology and Director of Laboratories, Children's Hospital of Pittsburgh of UPMC
4401 Penn Avenue, Suite Floor B
Pittsburgh, PA 15224
412-692-5650 Phone
412-692-6550 Fax

Education and Training

Medical School:

1982 MD National Autonomous University of Mexico (UNAM), México City, México

Residency:

1986 Pathology, National Autonomous University of México, México City, México

Fellowship:

1994 Pediatric Pathology, Children's Memorial Hospital, Northwestern University, Chicago, IL

Memberships

  • Pediatric and Developmental Pathology, Editor-in-Chief
  • Society for Pediatric Pathology
  • United States and Canadian Academy of Pathology
  • Paediatric Pathology Society
  • Asociación Mexicana de Patólogos
  • Sociedad Latinoamericana de Patologia Pediatrica (SLAPPE)
  • Sociedad Latinoamericana de Patologia (SLAP)
  • College of American Pathologists
  • Latin American Pathology Foundation, Ex-President
  • Southern CT Pathology Society

Board Certifications

  • The American Board of Pathology, Anatomic Pathology
  • Subspecialty certification by The American Board of Pathology, Pediatric Pathology

Publications

  • Adida, C., Berrebi, D., Peuchmaur, M., Reyes-Mugica, M., Altieri, D.C. Identification of prognostically unfavorable neuroblastoma by expression of the novel cancer anti-apoptosis gene, survivin. Lancet 351:882-883 (1998).
  • Reyes-Mugica, M., Lin Pei, Yakota, J., Reale, M.A. DCC loss of expression and neuroblastoma metastasis. Lab. Invest. 78:669-675 (1998).
  • Odaib, A.L., Shneider, B.L., Bennett, M.J., Pober, B.N., Reyes-Mugica, M., Friedman, A.L., Suchy, F.J., Rinaldo, P. A defect of Long-chain fatty acid transport in a patient with recurrent fulminant liver failure. N Engl. J. Med. 339:1752-1757 (1998).
  • Reyes-Mugica, M., Meyerhardt, J., Brierley, K.L., Rzasa, J., Rimm, D.L., Johnson, K.R., Wheelock, M.J., Reale, M.A. Truncated DCC reduces N-caherin mediated adhesion in neuroblastoma cells. Lab. Invest. 80:201-210 (2001).
  • Cheng E, Trombetta SE, Kovacs D, Beech RD, Ariyan S, Reyes-Mugica M, McNiff JM, Narayan D, Kluger HM, Picardo M, Halaban R. Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification. J Invest Dermatol. 2006 Jun 29; [Epub ahead of print] PMID: 16810302.
  • Gwin K, Cajaiba M, Caminoa-Lizarralde A, Picazo M, Nistal M, Reyes-Mugica M. Expanding the Clinical Spectrum of Frasier Syndrome. Pediatr Dev Pathol. 2007 Mar 22;:1 [Epub ahead of print].
  • Cajaiba MM, Benjamin D, Halaban R, Reyes-Mugica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. Am J Surg Pathol 2008 Jan;32(1):156-161.

    View Dr. Reyes-Múgica's full list of publications from PubMed.

Research Interests

I have been involved in studies of childhood tumors and defects of neural crest cell migration. In the first group, we have studied neuroblastoma, a neural crest derived neoplasm with heterogeneous biology and clinical behavior, in which the therapeutic advances have developed with difficulty. We also study another neural crest disorder called neurocutaneous melanosis. Patients with this condition are born with large pigmented nevi (moles) and later develop meningeal/brain melanocytic proliferations.  As a member of the Scientific Advisory Board of Nevus Outreach, Inc., a consultation service for conditions related to Giant Melanocytic Nevi and Neurocutaneous Melanosis is offered.  A third condition within our interests is Hirschsprung disease (congenital megacolon), in which neural crest-derived ganglion cells are not present in the colonic nervous system, leading to chronic constipation. Studies to improve our diagnostic ability are being conducted.

New avenues of research interest include the early pathology of cancer predisposition syndromes.  We are interested in seemingly trivial lesions that may foretell an increased cancer predisposition in the pediatric patient.  In addition, the pathology of pediatric testicular lesions has become a new field for our investigative efforts.

Biography Summary

Dr. Miguel Reyes-Múgica, born and educated in México began his career in the USA in 1990.  He graduated from the School of Medicine, National University of Mexico (UNAM) in 1982. He trained in Anatomic Pathology under Dr. Ruy Pérez Tamayo, a world recognized pathologist, scientist and medical writer.  Before migrating to the USA, Dr. Reyes was Attending Pathologist at the National Institute of Pediatrics (INP), in México City.  In 1990, Dr. Reyes began working under the mentorship of Dr. González-Crussí, a world-leading pediatric pathologist at Children’s Memorial Hospital (CMH), Northwestern University, in Chicago.  In 1994, Dr. Reyes accepted a position at the Department of Pathology at Yale, where he established the Program of Pediatric and Developmental Pathology, and remained as Director of such program for 14 years. During that period, he escalated the academic ladder and he was appointed Professor of Pathology and Pediatrics at the Yale University School of Medicine.  In July of 2008, he accepted the position of Chief of Pathology at the Children’s Hospital of Pittsburgh of UPMC, and Chief of the Division of Pediatric Pathology, at the Department of Pathology, UPMC.  Since 2001, Dr. Reyes-Múgica is Editor-in-Chief of the Journal Pediatric and Developmental Pathology, the leading journal in the field, and the official voice of the Society for Pediatric Pathology, and the Paediatric Pathology Society.

Dr. Reyes’ research activities are wide and cover a large extent of the general field of Pediatric Pathology.  He has concentrated his efforts in the area of pediatric neoplasia and developmental disorders, studying brain tumors and neural crest disorders, such as neuroblastoma, Hirschsprung disease, and neurocutaneous melanocytosis (NCM).  He explored neoplastic development and migration studying the role of the gene DCC in the ability of gliomas and neuroblastoma cells to migrate, disseminate and metastasize, and found a correlation between loss of DCC and increased metastatic potential of these lethal tumors.  He also studied the interaction between DCC and N-cadherin in neuroblastoma cells, providing original evidence towards the understanding of the physiological role of DCC. He has studied other features of neuroblastoma, exploring correlations between regulation of apoptosis and clinical behavior. In the same field of neurocristopathies, Dr. Reyes has studied the pathology, biology and genetics of nevomelanocytic lesions in children, specifically concentrating on NCM and giant pigmented nevi (GPN).  He has described a previously unrecognized form of GPN: Bulky Perineal Nevocytoma; he also studied the spectrum of lesions involving patients with Touraine syndrome or NCM.  His efforts have been sponsored and funded by the organization Nevus Outreach, Inc. (NOI), formed by patients and families with children afflicted by GPN and NCM.  Dr. Reyes is part of the Scientific Advisory Board of NOI. In the same field of neoplasia, Dr. Reyes has conducted studies on cancer predisposition syndromes, including Beckwith-Wiedemann, Frasier, Gorlin, Bloom and Sipple syndromes, among others. A more recent field of research is developmental testicular pathology.


Active Research Projects / Grants

  • Biological Studies on Neurocutaneous Melanosis and Giant Pigmented Nevi
  • ELGAN study
Last Update
December 23, 2008
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Last Update
December 23, 2008
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