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412-692-7280 Phone
412-692-6069 Fax

David J. Hackam, MD, PhD

Job Title Co-Director, Fetal Diagnosis and Treatment Center
Job Title Director, Training Program (START) for Medical
Job Title Associate Dean for Medical Student Research, University of Pittsburgh School of Medicine
Job Title Professor of Surgery, University of Pittsburgh School of Medicine
Job Title Associate Professor of Cell Biology and Physiology, University of Pittsburgh School of Medicine
Job Title Director, Center for Pediatric Surgical, Translational, and Regenerative Medicine
4401 Penn Avenue
Pittsburgh, PA 15224
412-692-7280 Phone
412-692-6069 Fax

Education and Training

Medical School:

1998 University of Toronto, Institute of Medical Science, Hospital for Sick Children, Toronto, Ontario, Canada
1992 University of Western Ontario, London, Ontario, Canada

Residency:

2000 Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada

Fellowship:

2002 Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pa.

Memberships

  • American Society for Biochemistry and Molecular Biology
  • American Academy of Pediatrics
  • American College of Surgeons, Candidate Member
  • Society of University Surgeons, Treasurer 
  • Shock Society
  • American Association for the Advancement of Science
  • American Gastroenterological Association
  • Surgical Infection Society, Ad Hoc By-Laws Committee, Editoral Board
  • American Society for Cell Biology
  • Association for Academic Surgery, Active Member, Nominating Committee
  • Canadian Medical Association
  • Ontario Medical Association
  • Alpha Omega Alpha Honor Medical Society
  • American Surgical Association

Board Certifications

  • The American Board of Surgery, Pediatric Surgery
  • The American Board of Surgery, General Surgery
  • Royal College of Physicians and Surgeons of Canada

Awards

  • Roberta Simmons Chair Honoree
  • Watson Award Nominee, Alpha Omega Alpha Medical Society (Nominated by University of Pittsburgh medical students)
  • Who's Who in Medical Sciences Education
  • Exceptional Patient Satisfaction Award, Children's Hospital of Pittsburgh
  • University of Pittsburgh School of Medicine, Excellence in Education Awards Nominee (Nominated by 1st & 2nd year medical students)
  • Outstanding Surgeon Award, Critical Care Staff, Children's Hospital of Pittsburgh
  • Outstanding Surgeon Award Nominee, Critical Care Staff, Children's Hospital of Pittsburgh
  • First Prize - Oral Presentation, Canadian Association of Pediatric Surgeons
  • William S. Fenwick Research Award, Faculty of Medicine, University of Toronto
  • First Prize - Oral Presentation, University of Toronto Annual Assembly of General Surgeons
  • Canadian Research Gold Medal for Specialty Residents in Surgery, Royal College of Physicians and Surgeons of Canada
  • Davis and Geck Award (Basic science contribution by clinical researcher),
    Canadian Association of General Surgeons
  • Andrew Sass-Kortsak Research Award (Nominated by all students/fellows),
    Hospital for Sick Children Research Institute
  • Basic Science Research Award (Abstract), Eastern Student Research Forum
  • Institute of Medical Science Research Award (Abstract), Eastern Student Research Forum at the University of Miami, University of Toronto
  • Canadian Association of Pediatric Surgeons Resident Award, First Place - Oral Presentation at Annual Meeting
  • American Society for Cell Biology Predoctoral Research Award, Basic Science Competition - Abstract
  • Institute of Medical Science Scientific Day, First Prize - Basic Science Poster
  • Gallie-Batemen Research Award, First Prize, Oral Presentation, University of Toronto
  • Resident Research Award for Novel Research Design and Experimentation,
    Physicians Services Incorporated, University of Toronto
  • University of Toronto Annual Assembly of General Surgeons, First Prize - Oral Presentation
  • Surgical Infection Society Resident Award, First Prize - Oral Presentation
  • Predoctoral Research Award, American Society of Cell Biology
  • Medical Research Council of Canada Research Fellowship
  • Resident Research Fellowship, Ethicon Society of University Surgeons
  • Hospital for Sick Children Research Fellowship
  • Province of Ontario Graduate Scholarship (Declined)
  • Laidlaw Prize - Honorable Mention, Institute of Medical Science, Toronto, Ontario, Canada
  • Gallie-Bateman Research Award, Honorable Mention, University of Toronto
  • Honorable Mention for Basic Science, Eastern Student Research Forum
  • Surgical Alumni Scholarship, University of Toronto
  • Research Fellowship, Hospital for Sick Children
  • Graduation Class of 1992, Ranked in the top ten, University of Western Ontario
  • Dean's Honor Roll, Academic Excellence in Medical School
  • Award of Academic Excellence, (Highest Mark in Undergraduate Cell Biology), University of Western Ontario
  • Dean's Honor Roll, Academic Excellence in First Year Undergraduate Biology, University of Western Ontario
  • Watson Chair Honoree, University of Pittsburgh School of Medicine Department of Surgery
  • American Surgical Association, Elected member

Publications

  • Neal MD, Sodhi CP, Jia H, Dyer M, Egan C, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T, Grant Z, Ozolek J, Hackam DJ. Toll like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53-upregulated modulator of apoptosis. J Biol Chem. 2012 Sep 6. [Epub ahead of print]
  • Misty Good, Richard Siggers, Chhinder P. Sodhi, Amin Afrazi, Feras Alkhudari, Charlotte E. Egan, Matthew D. Neal, Ibrahim Yazji, Hongpeng Jia, Joyce Lin, Maria F. Branca, Congrong Ma, Thomas Prindle, Zachary Grant, Sapana Shah,  Dennis Slagle II, Jose Paredes, John Ozolek,  George Gittes, David J. Hackam. Amniotic Fluid Inhibits Toll Like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium. Proceedings of the National Academy of Sciences (PNAS). In Press 2012.
  • Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis. PLoS One. 2012;7(5):e365560. Epub 2012 May 17. 

Research Interests

  • To understand the mechanisms governing the migration of intestinal epithelial cells during conditions of intestinal inflammation, such as necrotizing enterocolitis, Crohn's disease and infection. This information will hopefully provide novel therapeutic targets for treating these disorders.
  • To understand the mechanisms of phagocytosis of pathogens by macrophages in neonates during conditions of inflammation. This information will hopefully provide insights for enhancing the immune system during critical illness.
  • Initiating a large review of all patients with congenital diaphragmatic hernia to determine the optimal timing and mode of surgical repair.
  • Initiating a retrospective and prospective review of patients with tracheo-esophageal fistula to determine the factors influencing outcome in these patients.
  • Retrospective review of patients who have sustained traumatic intestinal injuries, to determine the optimal diagnostic modality and to determine strategies to improve their outcome.

Biography Summary

David J. Hackam, MD, PhD, is the Watson Family Professor of Surgery and Professor of Surgery, Cell Biology and Physiology at the University of Pittsburgh School of Medicine, and Attending Pediatric Surgeon in the Division of Pediatric General and Thoracic Surgery and co-director of the Fetal Diagnosis and Treatment Center of the Children’s Hospital of Pittsburgh of UPMC.
 
In 2011, Dr Hackam was named Associate Dean for Medical Student Research at the University of Pittsburgh School of Medicine. He joined the University of Pittsburgh School of Medicine in the Department of Surgery as assistant professor in 2002 after completing Pediatric Surgery fellowship training in Pittsburgh, and General Surgery training in Toronto. 
 
His laboratory is focused on unraveling the pathogenesis of necrotizing enterocolitis, and to developing novel treatments for it. To this end, he recently discovered that NEC is caused by increased expression and signaling of the innate immune receptor toll like receptor 4 (TLR4) within the newborn intestine, which when activated leads to breakdown of the mucosal barrier and impaired perfusion of the newborn intestine. Hackam has identified a novel class of molecules – many of which are found in breast milk – that can inhibit TLR4 activation, and in pre-clinical models these new agents serve both a therapeutic and prophylactic role in NEC. It is hoped that these studies – which are funded by several NIH and industry awards – will open up new avenues for our understanding of the pathogenesis of NEC, and offer novel treatments for this devastating disease.
 
Dr Hackam is passionate about training the next and current generation of clinician-scientists at all levels of training, and was recently elected President-Elect of the Society of University Surgeons.

 

Active Research Projects / Grants

  • TLR4 signaling in the pathogenesis of surgical necrotizing enterocolitis
  • Mechanisms of Epithelial Restitution in NEC
  • Pathogenesis and Treatment of Necrotizing Enterocolitis
  • A Novel Role for Enterocytes in the Maintenance of Gut Barrier Function: Phagocytosis
Last Update
October 15, 2013
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Last Update
October 15, 2013
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