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David H. Perlmutter, MD

David Perlmutter, MD
Job Title Physician-in-Chief and Scientific Director, Children's Hospital of Pittsburgh of UPMC
Job Title Vira I. Heinz Endowed Chairman, Department of Pediatrics
Job Title Distinguished Professor of Pediatrics, University of Pittsburgh School of Medicine
Job Title Professor of Cell Biology, University of Pittsburgh School of Medicine
4401 Penn Avenue
Pittsburgh, PA 15224
412-692-8071 Phone
412-692-5946 Fax

Education and Training

Medical School:

1978 St. Louis University School of Medicine, St. Louis, MO
 

Residency:

1980 Junior Resident, Children's Hospital of Philadelphia
1981 Assistant Chief Resident, Children's Hospital of Philadelphia
 

Fellowship:

1982 Clinical Fellow, GI and Nutrition, Children's Hospital Boston
1984 Research Fellow, GI and Nutrition, Children's Hospital Boston

Memberships

  • 2001 American Pediatric Society
  • 1994 Association of American Physicians
  • 1992 American Association for the Study of Liver Disease

Board Certifications

  • 1997 Pediatric Gastroenterology and Nutrition (recertification)
  • 1990 Pediatric Gastroenterology and Nutrition
  • 1983 Pediatrics

Awards

  • 1994 E. Mead Johnson Award for Research in Pediatrics

Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
    Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL
    Autophagy

Biography Summary

David H. Perlmutter, MD, is physician-in-chief and scientific director of Children’s Hospital of Pittsburgh of UPMC. He also is the Vira I. Heinz Professor and chair of the Department of Pediatrics at the University of Pittsburgh School of Medicine, as well as professor of cell biology and physiology at the university. Dr. Perlmutter earned his bachelor’s degree from the University of Rochester and his medical degree from St. Louis University School of Medicine. He trained in pediatrics at The Children’s Hospital of Philadelphia and in pediatric gastroenterology and nutrition at Children’s Hospital Boston.

After several years on the faculty of Harvard Medical School, Dr. Perlmutter joined the faculty at Washington University School of Medicine and St. Louis Children’s Hospital. From 1992–2001, he was the director of the Division of Gastroenterology and Nutrition at St. Louis Children’s, and in 1996 he became the first to hold the Donald Strominger Endowed Professorship of Washington University School of Medicine. In 2001 he left St. Louis to take his current position in Pittsburgh.

Dr. Perlmutter has carried out basic research on alpha-1-antitrypsin deficiency for more than 20 years. His work has led to many new concepts about the pathobiology of liver disease in this deficiency and has suggested several new concepts for chemoprophylaxis of chronic liver injury, hepatocellular carcinoma and emphysema in this genetic disease. He is the principal investigator on three NIH R01 grants in this area and also now holds four other NIH grants including the Child Health Research Center of Excellence Award for training pediatric physician scientist in the molecular basis of pediatric disease.

Dr. Perlmutter’s research has been recognized by numerous awards including the E Mead Johnson Award for Research in Pediatrics. He is a member of the American Society for Clinical Investigation and the Association of American Physicians. He has served as the president of the Society of Pediatric Research and is now a member of the Advisory Council of the National Institute for Diabetes, Digestive and Kidney Diseases. 

He is a member of numerous other advisory boards, foundation boards and editorial boards. Since joining Children’s Hospital in 2001, Dr. Perlmutter has led an effort to expand the hospital’s basic and clinical research program so that it is ideally poised to investigate the molecular basis of disease and to develop innovative therapies. Children’s Hospital is now the fastest growing pediatric research program in the country in terms of NIH funding from 2000–2005.

Last Update
March 24, 2014
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Last Update
March 24, 2014
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