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This research will help to determine normal versus abnormal levels of certain spinal fluids in children with inflammatory demyelinating disorders such as multiple sclerosis. These disorders affect the central nervous system, the brain, and the spinal cord and cause inflammation. This study will investigate protein molecules called cytokines that play an important role in inflammation. The study will measure cytokine levels in spinal fluid and blood samples from both children with demyelinating disorders as well as children who have had no inflammation of the brain.
Eligible candidates include children of both genders between the ages of 3 months and 17 years who have a demyelinating disorder. Also, children who do not have a demyelinating disorder but who recently had a spinal fluid exam performed, as part of their standard medical care, will be invited to participate.
Boys: 3 months to 17 years
Girls: 3 months to 17 years
Blood draws and an additional spinal fluid sample are required.
Duration: Not applicable
Department of Pediatrics
Gulay Alper, MD
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UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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