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Children's Hospital of Pittsburgh of UPMC
The major goal of Dr. Kolls' research is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. Presently, he is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. To this end, he studies cellular sources of IL-17A, IL-17F, and IL-22 in the lung and liver as well as their signaling in response to pulmonary infection or hepatitis.
Dr. Kolls also has a long standing interest to determine if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis. He also has a long-standing interest in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer. In these studies, he has identified that sub-populations of CD8+ T-cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii.
Dr. Kolls is presently using gene expression profiling and proteomics to define this effector activity. He also has a program in developing CD4-independent vaccination against AIDS-related opportunistic infections.
View Dr. Kolls' full list of publications from PubMed.
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4401 Penn Ave.3rd Floor
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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