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MD, Oregon Health & Science University Portland, OR
University of Pittsburgh School of Medicine Pittsburgh, PA
Dr. Eisses’ research focuses on understanding the role of epigenetic modifiers in regulating injury and recovery of the pancreas as it relates to pancreatic disease. His interests reside in the epigenetic regulation of the histone deacetylases (HDACs) in pancreatic recovery after injury, focusing on their action in distinct cell types within the pancreas – specifically pancreatic stellate cells (PSCs). Injury and inflammation activate PSCs resulting in the remodeling of the pancreatic microenvironment. Dr. Eisses postulates that an alteration in the epigenetic landscape during injury and subsequent recovery is necessary for the altered gene regulation at specific transcriptional sites within distinct pancreatic cell types. Epigenetic changes during PSC activation are required to allow ECM remodeling and to generate the necessary regenerative signals that allow pancreatic exocrine recovery. Prolonged injury or aberrant regulation of PSCs has been implicated in the development or promotion of several pancreatic diseases including chronic pancreatitis and pancreatic cancer. Ongoing studies aim to understand the important regulators of this process with an aim at developing therapeutic interventions.
Mechanisms of pancreatic injury and recovery. Epigenetic mechanisms in Pancreatic recovery following pancreatitis. Role of HDACs in modulating pancreatic recovery following injury.
View Dr. Eisses's full list of publications from PubMed.
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Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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