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MD, Oregon Health & Science University Portland, OR
University of Pittsburgh School of Medicine Pittsburgh, PA
Dr. Eisses’ research focuses on understanding the role of epigenetic modifiers in regulating injury and recovery of the pancreas as it relates to pancreatic disease. His interests reside in the epigenetic regulation of the histone deacetylases (HDACs) in pancreatic recovery after injury, focusing on their action in distinct cell types within the pancreas – specifically pancreatic stellate cells (PSCs). Injury and inflammation activate PSCs resulting in the remodeling of the pancreatic microenvironment. Dr. Eisses postulates that an alteration in the epigenetic landscape during injury and subsequent recovery is necessary for the altered gene regulation at specific transcriptional sites within distinct pancreatic cell types. Epigenetic changes during PSC activation are required to allow ECM remodeling and to generate the necessary regenerative signals that allow pancreatic exocrine recovery. Prolonged injury or aberrant regulation of PSCs has been implicated in the development or promotion of several pancreatic diseases including chronic pancreatitis and pancreatic cancer. Ongoing studies aim to understand the important regulators of this process with an aim at developing therapeutic interventions.
Mechanisms of pancreatic injury and recovery. Epigenetic mechanisms in Pancreatic recovery following pancreatitis. Role of HDACs in modulating pancreatic recovery following injury.
View Dr. Eisses's full list of publications from PubMed.
Patient comments are gathered from our Press Ganey Patient Satisfaction Survey and are displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
Total Comments: 18
He was very caring and seemed to really care about my daughter's health.
Dr. Eisses was very personable and friendly with my child. He answered all questions and concerns thoroughly.
so glad we made the decision to make my sons's appt with Dr. Eissis! He took so much time with us and thoroughly understood our concerns for our son.
I am very happy with Dr. Eisses! My son relates well to him, he is understanding and has really gotten to know my son's quirks and how to navigate them.
Dr. Eisses is patient and kind. He listened to and discussed my concerns. Dr. Eisses showed me and explained test results to me. Dr. Eisses also offered suggestions for my medicine and offered me the option of seeking an adult GI dr., but I feel comfortable staying in his care for now. So far, our experience has been good.
the provider spent a great amount of time with my son and explained everything in terms that both of us understood. was very respectful to my son.
The doctor was very patient and listened to everything I had to say. He also answered any questions or problems I was concerned about.
very impressed with kindness of staff and convience of not having to drive to Pittsburgh!
Dr. John Eisses has always been very nice with my child and gives enough time to explain the issue, he seems to be very caring and loving, we like him a lot too.
The Dr was more personable during this visit.
We appreciate Dr. Eisses approach with our child. He clearly has an understanding of the age of the patient and makes a point to include him in the discussion. We could not have asked for a more compassionate and patient physician.
very nice doctor
He was excellent. Very caring and listened very well and seemed concerned about everything.
Dr. John Eisses has always been very courteous and helpful!
I was VERY happy with everyone we came in contact with and the plan of action was exactly what I was hoping for.
doctor was excellent; would highly recommend.
Dr. Eises was very caring and patient during the visit. He explained things very well.
It was a very good and informative visit.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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