Mark Lowe, MD, PhD


Chief, Division of Pediatric Gastroenterology
Professor of Pediatrics, University of Pittsburgh School of Medicine
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Secondary Specialty:

Pediatric Gastroenterology


University of Miami School of Medicine
Miami, FL


St Louis Children's Hospital
Saint Louis, MO


St Louis Children's Hospital
Saint Louis, MO


Magee-Womens Hospital of UPMC
Children's Hospital of Pittsburgh of UPMC
UPMC Presbyterian South Surgery Center
UPMC Children's Surgery Centers


Research Interests

  • Pancreatic lipases and colipase in lipolysis and obesity
  • Structure-function of colipase and lipase
  • Physiochemical enzyme regulation in enzyme metabolism

View Dr. Lowe's full list of publications from PubMed.

Biography Summary

Mark E. Lowe, MD, PhD, joined Children's Hospital of Pittsburgh in 2003 as chief of the Division of Pediatric Gastroenterology, bringing with him a National Institutes of Health-supported laboratory investigating the role of enzymes, called lipases, in the digestion of dietary fats. Dr. Lowe is also a visiting professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Lowe earned a bachelor's degree in biology at Washington University in St. Louis in 1973. Four years later, he earned a doctorate in biochemistry at the University of Pennsylvania. He spent the next five years at the National Institutes of Health as a staff fellow in biochemistry and in pediatric metabolism, and as a senior staff fellow in pediatric metabolism. Dr. Lowe earned his medical degree in 1984 at the University of Miami School of Medicine in Florida.

He was an intern, resident and fellow in pediatrics at St. Louis Children's Hospital. Before leaving St. Louis for Pittsburgh, he held several faculty positions at Washington University School of Medicine, including associate professor of pediatrics and associate professor of molecular biology and pharmacology. He is a member of several professional societies, including the American Gastroenterological Association and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Dr. Lowe's work has earned him the Mead Johnson Nutritionals Award from the American Society for Nutritional Sciences, the American Heart Association Established Investigator and several other honors.

Dr. Lowe's laboratory is investigating a number of issues involving lipases and their roles in digestion and disease. His work includes studying how Itmap 1, a membrane protein, behaves as a protective mechanism against pancreatitis. Dr. Lowe's lab is also engaged in basic science to gain a deeper understanding of the function of lipases and procolipase in newborns - knowledge important to finding better ways to feed chronically ill infants. In addition, his lab is developing evidence that suggests that enterostatin, a peptide, plays an influential role in regulating appetite and determining body weight set point.

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Locations and Directions

  • Pediatric Gastroenterology, Hepatology and Nutrition

    Children's Hospital of Pittsburgh of UPMC

    4401 Penn Ave.
    Pediatric Gastroenterology, 3rd Floor
    Pittsburgh PA, 15224
    (412) 692-5180

  • Pediatric Gastroenterology, Hepatology and Nutrition

    Children's South

    205 Millers Run Road
    Bridgeville PA, 15017