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University of Pittsburgh School of Medicine Pittsburgh, PA
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As a Clinician-Scientist in the field of Pediatric Emergency Medicine, Dr. Manole’s research goal is to elucidate vascular pathways involved in cerebral vascular dysregulation and to develop therapeutic strategies that improve neurological outcome after pediatric asphyxial cardiac arrest. Throughout the past decade she has significantly contributed to the field of cardiac arrest and resuscitation research.
View Dr. Manole's full list of publications from PubMed.
Dr. Manole is Clinician, Researcher, and Teacher in Pediatric Emergency Medicine. After completing a fellowship in Pediatric Emergency Medicine in 2006, Dr. Manole pursued organized research training in Neurointensive Care at the Safar Center for Resuscitation Research supported by an NSRA Scholars Award from 2006 to 2008 under the mentorship of Drs. Patrick Kochanek and Robert Clark. She then successfully competed for the NIH K08 Mentored Career Development Award “Oxidative stress in Cerebral Blood Flow Dysregulation after Pediatric Cardiac Arrest,” which was funded by NICHD on its first submission in 2008. From 2008-2013, supported by the K08 award, she established research independence as the PI of university- and NIH- funded grants, including the American Heart Association award “Goal Directed Therapy Targeting Brain Oxygenation after Experimental Cardiac Arrest,” awarded in 2010, and the NIH R01 grant “CYP 450-mediated Cerebral Blood Flow Dysregulation and Neurotoxicity in Pediatric Cardiac Arrest,” awarded in 2013.
Dr. Manole is a prominent educator for the pediatric emergency medicine fellows at Children’s Hospital of Pittsburgh. She has served as research mentor for several fellows, participates in the development of the research curriculum for the Pediatric Emergency Medicine Fellowship, participates in fellow education, and is the Chair of the Fellowship Research Scholarship Oversight Committee. Additionally, Dr. Manole has significant contributions in teaching and mentoring undergraduate, postdoctoral and medical students, as well as residents and critical care fellows.
Dr. Manole serves as Associate Director of the Safar Center for Resuscitation Research, and is key member of fellowship research and teaching committees. Nationally, Dr. Manole has an active role in the mission of the American Heart Association.
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Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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