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For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
Mark Lowe, MD, PhD, has a longstanding interest in the mechanism behind the digestion of dietary fat. An important focus of his laboratory is defining the role of specific lipases at various ages. Through animal models, Dr. Lowe has demonstrated that a different lipase mediates dietary fat digestion in newborns compared to adults. The lab also studies the relationship between dietary fat digestion and appetite regulation. His laboratory has developed a mouse with a deficiency of procolipase, a pancreatic protein with an important role in both dietary fat digestion and appetite regulation. Finally, his laboratory has recently taken a new direction to understand the pathophysiology of pancreatitis and indomethacin-induced gastric injury. These studies center on a newly described protein, integral transmembrane protein 1 (Itmap1). Using a mouse model of Itmap1 deficiency, Dr. Lowe and his collaborators have shown that Itmap1 protects the mouse from pancreatitis and indomethacin-induced gastric injury. Ongoing studies aim at understanding the biology and function of Itmap1.
John Eisses' MD, PhD research focuses on understanding the role of epigenetic modifiers in regulating injury and recovery of the pancreas as it relates to pancreatic disease. His interests reside in the epigenetic regulation of the histone deacetylases (HDACs) in pancreatic recovery after injury, focusing on their action in distinct cell types within the pancreas – specifically pancreatic stellate cells (PSCs). Injury and inflammation activate PSCs resulting in the remodeling of the pancreatic microenvironment. Dr. Eisses postulates that an alteration in the epigenetic landscape during injury and subsequent recovery is necessary for the altered gene regulation at specific transcriptional sites within distinct pancreatic cell types. Epigenetic changes during PSC activation are required to allow ECM remodeling and to generate the necessary regenerative signals that allow pancreatic exocrine recovery. Prolonged injury or aberrant regulation of PSCs has been implicated in the development or promotion of several pancreatic diseases including chronic pancreatitis and pancreatic cancer. Ongoing studies aim to understand the important regulators of this process with an aim at developing therapeutic interventions.
David Keljo, MD, PhD, has a longstanding interest in inflammatory bowel disease (IBD). He currently has a study to evaluate the bone mineral density in pediatric patients’ IBD. It is thought that children with IBD are at risk for developing osteoporosis and its complications. Dr. Keljo is directly testing this impression by measuring bone density and markers of bone absorption in a cohort of newly diagnosed IBD patients over time. Together with this study, Dr. Keljo maintains a clinical registry of patients with IBD. This registry will be helpful in conducting outcomes research in pediatric IBD. David J Keljo, MD, PhD is the local principal investigator for several multicenter studies in IBD:
The Risk Stratification Study—evaluating the factors in newly diagnosed Crohn Disease patients that predict the rapid development of penetrating or structuring complications.
The PROTECT Study: Examining the factors predicting response to mesalamine, steroids or biological therapies in patients newly diagnosed with Ulcerative Colitis
The GEM Study: Evaluating siblings of IBD patients who themselves have not yet developed IBD, to Determine the factors which might predict their subsequent development of IBD.
Arvind Srinath’s, MD research focuses on
subspecialty medical education, in particular
pediatric gastroenterology curriculum development, in addition to functional
A Multicenter, Long-term
Safety, Efficacy, and Pharmacokinetics Study of Lubiprostone in Paediatric
Subjects Aged ≥ 6 Years to < 18 Years with Functional Constipation. This phase 3
study aims to assess the efficacy of lubiprostone in pediatric functional
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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