Children's Hospital is part of the UPMC family.
Our Sites
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
Lennox-Gastaut syndrome is a severe type of epilepsy characterized by three factors:
The peak age of onset is between the ages of 3 and 5 years. There is a slightly greater prevalence in boys than girls. It is estimated that between 20 and 60 percent of children with this syndrome have a prior history of infantile spasms. This syndrome is rare and occurs in about .3 in every 1,000 live births.
The first sign in about one-third of children with Lennox-Gastaut syndrome is a prolonged seizure. The child usually has multiple seizures throughout the day. Tonic seizures (muscle stiffening) are the most common and usually occur during sleep. They usually last about 10 seconds, but they can last up to one minute.
Many of Lennox-Gastaut’s symptoms are common with other epileptic conditions, so a diagnosis of Lennox-Gastaut may be delayed until the child’s behavior is observed over a period of time. An EEG will show a slow spike and wave pattern that is specific to this syndrome. Brain abnormalities are common with this syndrome, so physicians will perform brain imaging tests. The physician will also check for signs of prior seizures, intellectual disability, hearing and visual impairment, and tuberous sclerosis which are sometimes present in children with Lennox-Gastaut.
Children with Lennox-Gastaut are typically treated with multiple epileptic drugs to control their seizures.
A vagus nerve stimulator, which is an implantable device that stimulates the vagus nerve within the left side of the neck, has shown to reduce the frequency and/or intensity of seizures of children with this type of epilepsy. Read more about vagus nerve stimulator implantation at Children’s.
Corpus callosotomy is also effective.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With MyCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.