Studies Open for Enrollment

Antibiotic Versus Placebo for Persistent Purulent Nasal Discharge (PPND) in Young Children

When a child has a cold, it is not known if these symptoms are caused by a bacteria or virus. If a bacterial infection is the cause, antibiotics may be helpful. However, symptoms from a virus will subside without specific treatment. This study will help to learn if antibiotics are better than placebo in treating children with persistent purulent nasal discharge (thick colored nasal mucus).

Candidates
Children 2 to 23 months old treated at either Children’s Hospital of Pittsburgh of UPMC or at Children’s Community Pediatrics, who have been determined to have a cold with no evidence of the streptococcal bacteria based upon a throat culture. Approximately 100 children will be enrolled for this study over two years.
Boys: 2-23 months old
Girls: 2-23 months old

Requirements
Two office visits and additional telephone contact with the study team will be required throughout this 10-day study. A physical exam is required and other testing may be performed. The study drug, Augmentin, or a placebo will be assigned through random selection to be administered for 10 days. Parents will keep a journal of the child’s condition during the study. If the illness worsens during this period, the child should be returned to the office for care.
Visits: 2
Duration: 10 days

Status:  Open for Enrollment

How to Participate
To get started, please contact:
Cheryl Rosenberg, LPN, CCRC
412-692-7351

Additional Resources
Children’s Community Pediatrics

Principal Investigator
Judith Martin, MD
Infectious Diseases

Source of Support
GlaxoSmithKline