Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Download our mobile app today - it's free!
The gastrointestinal (GI) tract is one of the largest immune organs in the body. It is also host to 500 to 1000 different bacterial species and as much as 1014 bacteria. The majority of these bacteria represent commensals that play an important role in the development and maintenance of the host immune system. The careful interplay between the immune cells and the commensal bacteria allow for the host’s immune system’s ability to respond to pathogenic bacteria but to be tolerant to the commensal ones. However, how homeostasis is established and maintained in humans is very poorly understood.
Through translational studies of human tissue throughout gestation as well as from neonates and young children, the Konnikova Lab is interested in deciphering how homeostasis is established and maintained.
Dysregulation of the GI immune homeostasis leads to a number of diseases such as necrotizing enterocolitis (NEC), very early onset inflammatory bowel disease (VEO-IBD) and IBD. To facilitate with studying mucosal immunity in health and diseases, we have adapted mass cytometry (CyTOF) to perform deep immunophenotyping and functional analysis of immune cells at mucosal surfaces. Additionally, we have developed a cryopreservation method to store tissue directly with preservation of viability and functionality. These advances have allowed us to study immune dysregulation in various diseases such as NEC, VEOIBD and IBD.
CyTOF analysis of immune cells in the small intestine of a VEOIBD patient (P1) and patients with and without IBD. Kotlarz et al, Nature Genetics, 2018.
FACS analysis of Th17 and IL17 production in an IL10 receptor deficient patient. Shouval and Konnikova et al, IBD, 2017.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.