Publications

The following is a summary of just some of the published articles by members of the Center for Pediatric Research in Obesity and Metabolism.

Pharmacokinetic and Pharmacodynamic Profile of the Sodium-glucose Co-transporter-2 Inhibitor Empagliflozin in Young People With Type 2 Diabetes: A Randomized Trial
Laffel LMB, Tamborlane WV, Yver A, Simons G, Wu J, Nock V, Hobson D, Hughan KS, Kaspers S, Marquard J
Diabetic Medicine
2018 Apr 14

Impaired Lipolysis, Diminished Fat oxidation and Metabolic Inflexibility in Obese Girls with Polycystic Ovary Syndrome
Kim JY, Tfayli H, Michaliszyn S, Arslanian S
The Journal of Clinical Endocrinology & Metabolism
2018 Feb

Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT)
Kim JY, Nasr A, Tfayli H, Bacha F, Michaliszyn S, Arslanian S
Diabetes
2017 Dec

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate
Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT
Hypertension
2017 Jul 24

Response to Letter “Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.”
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jun 6

Pediatric Obesity – Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline
Styne DM, Arslanian S, Connor EL, Farooqi IS, Murad H, Silverstein, JH, Yanovski JA
The Journal of Clinical Endocrinology & Metabolism
2017 Jan 31

Adiponectin, Insulin Sensitivity, β-cell function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY
TODAY Study Group: Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond M, Levitsky L, Nadeau K, White N, Willi S
Diabetes Care
2017 Jan

The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth
Kim JY, Michaliszyn SF, Nasr A, Lee SJ, Tfayli H, Hannon T, Hughan KS, Bacha F, Arslanian S
Diabetes Care
2016 Aug

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice
Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH
Endocrinology
2016 Mar

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT
Circulation
2016 Feb 23

Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome
Hughan KS, Tfayli H, Warren-Ulanch JG, Barinas-Mitchell E, Arslanian S
Journal of Pediatrics
2016 Jan

The Changing Face of Diabetes in Youth: Lessons Learned from Studies of Type 2 Diabetes
Hannon T, Arslanian S
Annals of the New York Academy of Sciences
2015 Oct 8

β-cell Function, Incretin Effect and Incretin Hormones in Obese Youth along the Span of Glucose Tolerance from Normal to Prediabetes to Type 2 Diabetes
Michaliszyn S, Mari A, Lee S, Bacha F, Tfayli H, Farchoukh L, Ferrannini E, Arslanian S
Diabetes
2014 Nov

Coronary Artery Calcification in Obese Youth: What are the Phenotypic and Metabolic Determinants?
Bacha F, Edmundowicz D, Sutton-Tyrell K, Lee S, Tfayli H, Arslanian S
Diabetes Care
2014 Sep

Restoring Insulin Secretion (RISE): Design of Studies of β-Cell Preservation in Prediabetes and Early Type 2 Diabetes Across the Life Span
RISE Study Group: Nadeau K, Mather K, Arslanian S, Buchanan T, Caprio S, Edelstein S, Ehrmann, D, Savage P, Kahn S
Diabetes Care
2014 Mar

Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-Cell Function in TODAY
TODAY Study Group: Arslanian S, Pyle L, Payan M, Bacha F, Caprio S, Haymond M, Levitsky LL, Goland R, White N, Willi SM
Diabetes Care
2013 June 1

β-Cell Lipotoxicity After an Overnight Intravenous Lipid Challenge and Free Fatty Acid Elevation in African American Versus American White Overweight/obese Adolescents
Hughan KS, Bonadonna RC, Lee S, Michaliszyn SF, Arslanian SA
The Journal of Clinical Endocrinology & Metabolism
2013 May

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH
Diabetes
2011 Nov

FoxO1 Mediates Insulin-dependent Regulation of Hepatic VLDL Production in Mice
Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M, Dong HH
The Journal of Clinical Investigation
2008 Jun 2

Foxo1 Mediates Insulin Action on apoC-III and Triglyceride Metabolism
Altomonte J, Cong L, Harbaran S, Richter A, Xu J, Meseck M, Dong HH
The Journal of Clinical Investigation
2004 Nov 15