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This multicenter study is being done to determine whether chemical markers in blood, urine, and stool can serve as early indicators for worsening heart function in patients who have had a Fontan procedure. This is an important step towards developing interventions to improve quality of life and overall functioning in individuals who have had this procedure. Fontan surgery involves diverting venous blood from the right atrium to the pulmonary arteries without passing through the right ventricle. It is sometimes done in pediatric cases as treatment for heart valve defects such as tricuspid atresia or pulmonary atresia, or for a pumping abnormality such as hypoplastic left heart syndrome or hypoplastic right heart syndrome.
This study is open to men and women ages 18 through 40 who are being followed at the Adult Congenital Heart Disease Center of Children’s Hospital of Pittsburgh of UPMC and who had a Fontan surgery at least 4 years prior or a Fontan revision or conversion at least 1 year prior.
Males and Females: Ages 18 through 40
During a single visit, medical records will be reviewed and participants will need to complete questionnaires about their health, physical activity, mental health and quality of life. Various body measurements will be taken and additional tests will be done using electrocardiogram, cardiac magnetic resonance imaging, and collection of blood, urine, and stool samples.
Visits: A single 6-hour visit
Duration: Not applicable
Cincinnati Children’s Hospital Medical Center
For more information about the study or enrollment, please contact:
Morgan LeSuer-Mandernack, study coordinator
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.