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The goal of this Phase III, multi-center study is to better understand how well acetaminophen works at a particular dosage level when given intravenously. For treatment of pain or fever, doctors frequently use acetaminophen, the active ingredient in Tylenol®. Acetaminophen, given by pill or suppository, is well understood. This study will help to understand the effectiveness and potential side effects of acetaminophen when given intravenously to children.
Inpatients of both genders, from newborns to age 17, requiring acetaminophen for treatment of pain or fever may participate in this study.
Boys: Newborns up to age 17
Girls: Newborns up to age 17
Participants will be given acetaminophen intravenously on a schedule and with a dosage based on body weight over 5 to 7 days while in the hospital. A follow-up visit will be conducted 7 days after the last day the child receives intravenous acetaminophen. The clinic will make a follow-up phone call to check on the child’s health 30 days later.
Visits: 1 beyond inpatient period
Duration: About 1 month
Cadence Pharmaceuticals, Inc.
Study Description at National Institutes of Health
Ayse Fidan Genc, MD
To get started, please contact:
Kathleen Fertal, RN, BSN, CCRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.