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This study will measure whether the drug dexmedetomidine is as effective as or better than the drug adenosine for treatment of supraventricular tachycardia (SVT). SVT is an accelerated heart rhythm caused by dysfunction of the heart’s electrical system. Researchers have observed that dexmedetomidine, which is more commonly used as a sedative, has anti-arrhythmic properties and believe it may have the ability to terminate SVT without certain side effects frequently seen with the standard medicine used for SVT.
A physician’s referral is required for this study, which is open only to children and young adults who have a history of SVT and have been scheduled for a cardiac electrophysiology study for evaluation of their SVT.
Males and Females: Ages 5 to 30
Patients experiencing SVT during their electrophysiology study will be given adenosine. If it does not terminate the SVT, then dexmedetomidine will be given. If adenosine terminates the SVT, then dexmedetomidine will be given during a subsequent electrophysiology study. If neither treatment works, physician investigators will end the SVT using other standard of care methods. Patients will be followed for adverse events as part of this study until discharged from the hospital or for 1 week, whichever comes first.
Visits: None beyond what is required for the electrophysiology study
Duration: Not Applicable
University of Pittsburgh
Study Description at National Institutes of Health
For information, please contact:
Kelli Shepler, CRC
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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