Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
The purpose of this research study is to investigate the safety of pharmacological therapies that may potentially improve pediatric outcomes after traumatic brain injury (TBI). TBIs are the leading cause of death and disability among children and young adults. Researchers hope to demonstrate that combinational therapy with a membrane transporter and antioxidant are safe after TBI and can help overcome barriers to the brain, synergistically improving bioavailability and efficacy of the antioxidant content of the body and central nervous system after TBI.
Subject to certain exclusion criteria, this study is enrolling patients of both genders between the ages of 2 to 18 years who have been admitted to the pediatric intensive care unit (PICU) of Children’s Hospital of Pittsburgh of UPMC with severe TBI.
Females: Ages 2 to 18 years
Males: Ages 2 to 18 years
Patients will be randomly assigned to receive either a placebo or a combination of probenecid and N-acetyl cysteine (Pro-NAC) via nasogastric or orogastric tube for 3 days. Patients will be monitored for drug safety and to measure antioxidant reserve in serum and cerebral spinal fluid with the presumption that maintaining antioxidant levels within the brain may be neuroprotective.
Visits: Occurs while patient is in the PICU
Duration: PICU length of stay
University of Pittsburgh
National Institutes of Health
National Institute of Neurological Disorders and Stroke
Study Description at National Institutes of Health
Michael J. Bell, MD
Robert Clark, MD
For information, please contact:
Michael J. Bell, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to: