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The purpose of this observational study is to use brain imaging and cognitive testing to measure amyloid plaque deposits in the brains of healthy patients with Down syndrome. Individuals with Down syndrome have an extra chromosome number 21, which is also the chromosome responsible for production of amyloid. Amyloid plaques can build in the brain and are related to memory loss and Alzheimer’s disease. Because of the extra chromosome 21, people with Down syndrome may develop amyloid deposits much earlier than people without Down syndrome. Researchers will use magnetic resonance imaging (MRI) and positron emission tomography, more commonly known as a PET scan, along with other tests, which may prove to be predictive of increased risk for development of Alzheimer’s disease.
Subject to certain exclusion criteria, this study is open to men and women age 25 years and older who have been diagnosed with Down Syndrome.
Males: 25 and up
Females: 25 and up
The study will consist of four visits over a 4 year period at the John Merck Outpatient Center in the South Side of Pittsburgh. Each visit will take approximately two days to complete. A relative or caregiver will complete a set of questionnaires while the adult with Down Syndrome undergoes a physical examination and completes a range of cognitive tests. Some of the visits will also include an MRI and PET scans. In addition, there will be a blood draw.
Duration: 2 days
John Merck Outpatient Center, 10th St. and Bingham St. Pittsburgh, PA 15203
Participants will be compensated for their time and expenses. Funds are available for participants and caregivers who reside a distance from Pittsburgh to stay overnight.
University of Pittsburgh Medical Center
Cathy Wolfe, M.Ed., BCBA
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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