Respiratory Illness Diagnostic Test: The RADICAL Study

Rapid Diagnostic Test for the Categorization of Acute Respiratory Illness

Protocol Description

This multi-center study evaluates the ability of an investigational diagnostic test to identify the cause of respiratory infections. Currently, no single test can quickly determine if a child’s respiratory symptoms and illness are due to a virus, bacteria, fungus or not caused by an infection at all. Using samples collected during the medical evaluation, researchers will study gene expression – examining how genes are turned on or off in response to the illness – seeking patterns that can lead to effective diagnoses.

Eligibility Criteria

Pediatric patients being evaluated in the Emergency Room of UPMC Children’s Hospital of Pittsburgh with symptoms of acute respiratory illness are eligible to participate.
Males and Females: Ages 2 years and up

Requirements

Blood and urine samples will be collected, and a nasal or throat swab may also be collected. Samples will be sent to a lab for analysis along with medical record information and will not be used in connection with immediate treatment for the child’s condition. Researchers will follow up within 12 months to check patient response to treatment.
Visits: None beyond normal treatment for these conditions
Duration: 12 months

Status: Open to Enrollment

Source(s) of Support

National Institutes of Health
Duke University
Host Response, Inc.
BioFire Diagnostics

Primary Investigator

Robert W. Hickey, MD

Contact Information

For more information about the study or enrollment, please contact:
Research Coordinator
412-864-8380